Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.36 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12344538 | 0.86 | LMNA (0.48) | LMNASMN1; SMN2ALDH1A1EPHX2TDP1 | |
| SCHEMBL6444526 | 0.84 | LMNA (0.47) | LMNASMN1; SMN2ALDH1A1EPHX2TDP1 | |
| SCHEMBL1778693 | 0.81 | SMN1; SMN2 (0.61) | LMNASMN1; SMN2ALDH1A1EPHX2TDP1 | |
| SCHEMBL5263064 | 0.78 | LMNA (0.55) | LMNASMN1; SMN2ALDH1A1EPHX2TDP1 | |
| SCHEMBL17352418 | 0.78 | LMNA (0.55) | LMNASMN1; SMN2ALDH1A1EPHX2TDP1 | |
| SCHEMBL17352352 | 0.75 | EPHX2 (0.58) | LMNASMN1; SMN2ALDH1A1EPHX2L3MBTL1 | |
| SCHEMBL14573044 | 0.73 | EPHX2 (0.53) | LMNASMN1; SMN2ALDH1A1EPHX2TDP1 | |
| SCHEMBL1073954 | 0.73 | LMNA (0.48) | LMNASMN1; SMN2ALDH1A1EPHX2TDP1 | |
| SCHEMBL5385637 | 0.73 | LMNA (0.48) | LMNASMN1; SMN2ALDH1A1EPHX2TDP1 | |
| SCHEMBL8968921 | 0.73 | ALDH1A1 (0.51) | LMNASMN1; SMN2ALDH1A1EPHX2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3269395-A1 | AMINOALCOHOL LIPIDOIDS AND USES THEREOF | Massachusetts Institute Of Technology (US) | 2018-01-17 | — | — | EP | disclosed |
| US-20170204075-A1 | AMINOALCOHOL LIPIDOIDS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2017-07-20 | — | — | US | disclosed |
| EP-2365962-B1 | AMINOALCOHOL LIPIDOIDS AND USES THEREOF | MASSACHUSETTS INST TECHNOLOGY (US) | 2017-07-05 | — | — | EP | disclosed |
| US-9556110-B2 | Aminoalcohol lipidoids and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2017-01-31 | — | — | US | disclosed |
| US-20160137785-A1 | POLY(BETA-AMINO ALCOHOLS), THEIR PREPARATION, AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2016-05-19 | — | — | US | disclosed |
| US-9193827-B2 | Poly(beta-amino alcohols), their preparation, and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-11-24 | — | — | US | disclosed |
| US-20150203439-A1 | AMINOALCOHOL LIPIDOIDS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2015-07-23 | — | — | US | disclosed |
| US-8969353-B2 | Aminoalcohol lipidoids and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-03-03 | — | — | US | disclosed |
| US-20140322309-A1 | ALPHA-AMINOAMIDINE POLYMERS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLO (US) | 2014-10-30 | — | — | US | disclosed |
| US-20130302401-A1 | POLY(BETA-AMINO ALCOHOLS), THEIR PREPARATION, AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-11-14 | — | — | US | disclosed |
| WO-2013090861-A1 | ALPHA-AMINOAMIDINE POLYMERS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-06-20 | — | — | WO | disclosed |
| US-8450298-B2 | Aminoalcohol lipidoids and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-05-28 | — | — | US | disclosed |
| US-8450298-B2 | Aminoalcohol lipidoids and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-05-28 | — | — | US | disclosed |
| WO-2012027675-A2 | POLY(BETA-AMINO ALCOHOLS), THEIR PREPARATION, AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-03-01 | — | — | WO | disclosed |
| US-20110293703-A1 | AMINOALCOHOL LIPIDOIDS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2011-12-01 | — | — | US | disclosed |
| US-20100331234-A1 | AMINOALCOHOL LIPIDOIDS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331234-A1 | AMINOALCOHOL LIPIDOIDS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2010-12-30 | — | — | US | disclosed |
| WO-2010053572-A2 | AMINOALCOHOL LIPIDOIDS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2010-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150203439-A1 | AMINOALCOHOL LIPIDOIDS AND USES THEREOF | PHOSPHO1, PNMT, AASDHPPT | LMNA 314/4885SMN1; SMN2 2665/4885ALDH1A1 568/4885 |
| US-20140322309-A1 | ALPHA-AMINOAMIDINE POLYMERS AND USES THEREOF | AAAS, AADAT, INMT | LMNA 136/4885SMN1; SMN2 1006/4885ALDH1A1 257/4885 |
| US-20110293703-A1 | AMINOALCOHOL LIPIDOIDS AND USES THEREOF | PHOSPHO1, PNMT, AASDHPPT | LMNA 314/4885SMN1; SMN2 2665/4885ALDH1A1 568/4885 |
| US-20160137785-A1 | POLY(BETA-AMINO ALCOHOLS), THEIR PREPARATION, AND USES THEREOF | PDGFA, MIF, FIBP | LMNA 1746/4885SMN1; SMN2 4518/4885ALDH1A1 76/4885 |
| US-20170204075-A1 | AMINOALCOHOL LIPIDOIDS AND USES THEREOF | PHOSPHO1, PNMT, AASDHPPT | LMNA 314/4885SMN1; SMN2 2665/4885ALDH1A1 568/4885 |
| US-20100331234-A1 | AMINOALCOHOL LIPIDOIDS AND USES THEREOF | PHOSPHO1, PNMT, AASDHPPT | LMNA 314/4885SMN1; SMN2 2665/4885ALDH1A1 568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.