Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 7/20 | 0.49 |
| ▸ | PDE5A | O76074 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5259174 | 0.86 | PDE5A (0.44) | DHPSPDE5AEGFRPDGFRBJAK2 | |
| SCHEMBL15966833 | 0.80 | ALDH1A1 (0.49) | PDGFRBMAPTMEN1KMT2ATUBB4A | |
| SCHEMBL5258591 | 0.79 | WHR1 (0.55) | DHPSEGFRPDGFRBTHRBLMNA | |
| SCHEMBL7261425 | 0.79 | PDE1B (0.60) | DHPSPDE5AEGFRPDGFRBJAK2 | |
| SCHEMBL5259886 | 0.79 | HPGD (0.40) | PDE5AEGFRLMNAMAPTTP53 | |
| SCHEMBL7268608 | 0.78 | PDE5A (0.51) | DHPSPDE5ATHRBMEN1KMT2A | |
| SCHEMBL7266347 | 0.78 | MEN1 (0.53) | PDE5ATHRBLMNAMAPTMEN1 | |
| SCHEMBL7261986 | 0.77 | NPSR1 (0.47) | PDE5AEGFRLMNAMAPTMEN1 | |
| SCHEMBL7261507 | 0.77 | ALDH1A1 (0.52) | PIK3CAPIK3CBPIK3CGMAPT | |
| Hydrochloric Acid SCHEMBL7262070 | 0.77 | PDE5A (0.50) | PDE5ATHRBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1040101-B1 | SUBSTITUTED 2-ARYL-4-AMINO-CHINAZOLINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-04-25 | — | — | EP | disclosed |
| US-6613772-B1 | Drugs such as 2-(p-chlorophenyl-4-(4-hydroxybutyl)amino-6,7,8 -trimethoxyquinazoline used for activation of guanylate cyclase and modulation of cyclic guanosine monophosphate | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-09-02 | — | — | US | disclosed |
| EP-1040101-A1 | SUBSTITUTED 2-ARYL-4-AMINO-CHINAZOLINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | Aventis Pharma Deutschland GmbH (DE) | 2000-10-04 | — | — | EP | disclosed |
| WO-1999032460-A1 | SUBSTITUTED 2-ARYL-4-AMINO-CHINAZOLINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-07-01 | — | — | WO | disclosed |