Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | STAT6 | P42226 | 1/20 | 0.44 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7261507 | 0.87 | ALDH1A1 (0.52) | NPSR1ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7267798 | 0.87 | HTR3E (0.45) | NPSR1ALDH1A1CYP1A2CYP2C19KDM4E | |
| SCHEMBL8134950 | 0.85 | KDM4E (0.43) | NPSR1ALDH1A1KDM4ESTAT6NTSR1 | |
| SCHEMBL7262055 | 0.85 | TGFBR1 (0.43) | NPSR1ALDH1A1KDM4ESTAT6NTSR1 | |
| SCHEMBL7267789 | 0.85 | KDM4E (0.43) | NPSR1ALDH1A1KDM4ESTAT6NTSR1 | |
| SCHEMBL7267753 | 0.84 | NPSR1 (0.63) | NPSR1ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7268539 | 0.84 | NTSR1 (0.61) | NPSR1ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7261372 | 0.83 | MAPT (0.46) | NPSR1ALDH1A1KDM4ESTAT6NTSR1 | |
| SCHEMBL7261520 | 0.82 | ACHE (0.53) | NPSR1ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5261786 | 0.82 | ACHE (0.53) | NPSR1ALDH1A1KDM4ESTAT6NTSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6613772-B1 | Drugs such as 2-(p-chlorophenyl-4-(4-hydroxybutyl)amino-6,7,8 -trimethoxyquinazoline used for activation of guanylate cyclase and modulation of cyclic guanosine monophosphate | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-09-02 | — | — | US | disclosed |
| EP-1040101-A1 | SUBSTITUTED 2-ARYL-4-AMINO-CHINAZOLINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | Aventis Pharma Deutschland GmbH (DE) | 2000-10-04 | — | — | EP | disclosed |
| WO-1999032460-A1 | SUBSTITUTED 2-ARYL-4-AMINO-CHINAZOLINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-07-01 | — | — | WO | disclosed |