Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5263549 | 1.00 | ALDH1A1 (0.35) | ALDH1A1MAPTKDM4EMAPK1GAA | |
| SCHEMBL429986 | 0.76 | ALDH1A1 (0.45) | ALDH1A1MAPTKDM4EMAPK1GAA | |
| SCHEMBL429018 | 0.74 | ALDH1A1 (0.37) | ALDH1A1KDM4EGAATSHRSMN1; SMN2 | |
| SCHEMBL429019 | 0.74 | ALDH1A1 (0.37) | ALDH1A1KDM4EGAATSHRSMN1; SMN2 | |
| SCHEMBL425787 | 0.73 | HSD17B10 (0.39) | ALDH1A1MAPTKDM4EMAPK1TSHR | |
| SCHEMBL428060 | 0.64 | TDP1 (0.40) | ALDH1A1MAPTKDM4EMAPK1TSHR | |
| SCHEMBL428061 | 0.64 | TDP1 (0.40) | ALDH1A1MAPTKDM4EMAPK1TSHR | |
| SCHEMBL430744 | 0.62 | MAPT (0.47) | ALDH1A1MAPTKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL426942 | 0.62 | PTGS2 (0.42) | ALDH1A1MAPTKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL428326 | 0.61 | GPR35 (0.42) | ALDH1A1MAPTTSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786822-A1 | FUSED TRICYCLIC DERIVATIVES FOR THE TREATMENT OF PSYCHOTIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006024517-A1 | FUSED TRICYCLIC DERIVATIVES FOR THE TREATMENT OF PSYCHOTIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-03-09 | — | — | WO | disclosed |