Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | RHOC | P08134 | 1/20 | 0.32 |
| ▸ | RHOA | P61586 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1295656 | 0.86 | IDO1 (0.48) | IDO1DAOCES2RHOCRHOA | |
| SCHEMBL28676177 | 0.83 | IDO1 (0.40) | IDO1TSHRMAPK1MAOBTAAR1 | |
| SCHEMBL864911 | 0.79 | IDO1 (0.47) | IDO1TSHRMAPK1MAOBTAAR1 | |
| SCHEMBL1295918 | 0.78 | RXRA (0.41) | IDO1DAOALDH1A1CES2 | |
| SCHEMBL10200704 | 0.78 | IDO1 (0.45) | IDO1TSHRMAPK1MAOBTAAR1 | |
| SCHEMBL13675004 | 0.78 | IDO1 (0.45) | IDO1TSHRMAPK1MAOBTAAR1 | |
| SCHEMBL23536705 | 0.77 | IDH1 (0.39) | IDO1DAOMAPT | |
| SCHEMBL5592016 | 0.77 | NOTUM (0.41) | IDO1DAOCES2 | |
| SCHEMBL22783327 | 0.77 | IDO1 (0.37) | IDO1TSHRMAPK1DAOMAPT | |
| SCHEMBL5426047 | 0.76 | IDO1 (0.39) | IDO1TSHRMAPK1MAOBNR2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797067-A1 | NEW HETEROCYCLIC AMIDES | AstraZeneca AB (SE) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006033620-A1 | NEW HETEROCYCLIC AMIDES | ASTRAZENECA AB (SE) | 2006-03-30 | — | — | WO | disclosed |