Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2884326 | 0.97 | SIRT6 (0.48) | SIRT6ADRB1MAPTALDH1A1POLB | |
| SCHEMBL6493247 | 0.75 | MAPT (0.56) | SIRT6ADRB1MAPTALDH1A1POLB | |
| SCHEMBL2884332 | 0.71 | SIRT6 (0.50) | SIRT6ADRB1MAPTALDH1A1POLB | |
| SCHEMBL30768858 | 0.67 | CRBN (0.50) | POLB | |
| SCHEMBL13570120 | 0.66 | ACHE (0.55) | SIRT6MAPTALDH1A1POLBMEN1 | |
| SCHEMBL4067852 | 0.66 | MAPT (0.56) | SIRT6ADRB1MAPTALDH1A1POLB | |
| SCHEMBL5461036 | 0.66 | SIRT6 (0.47) | SIRT6ADRB1MAPTALDH1A1POLB | |
| SCHEMBL31011685 | 0.66 | MAPT (0.56) | SIRT6ADRB1MAPTALDH1A1POLB | |
| SCHEMBL8448356 | 0.65 | HRH3 (0.56) | SIRT6ADRB1MAPTALDH1A1POLB | |
| SCHEMBL2537629 | 0.65 | POLB (0.49) | SIRT6ADRB1MAPTALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781663-A2 | ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT | Sanofi-Aventis Deutschland GmbH (DE) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006018280-A2 | ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-02-23 | — | — | WO | disclosed |