Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.62 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.52 |
| ▸ | IDO1 | P14902 | 2/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8986807 | 1.00 | LOXL2 (0.62) | LOXL2TAAR1SLC6A2SLC6A3IDO1 | |
| SCHEMBL11601065 | 1.00 | LOXL2 (0.62) | LOXL2TAAR1SLC6A2SLC6A3IDO1 | |
| Hydrochloric Acid SCHEMBL6849321 | 0.98 | LOXL2 (0.60) | LOXL2TAAR1SLC6A2SLC6A3IDO1 | |
| Hydrochloric Acid SCHEMBL6849318 | 0.98 | LOXL2 (0.60) | LOXL2TAAR1SLC6A2SLC6A3IDO1 | |
| Hydrochloric Acid SCHEMBL9116903 | 0.98 | LOXL2 (0.60) | LOXL2TAAR1SLC6A2SLC6A3IDO1 | |
| Hydrochloric Acid SCHEMBL9194807 | 0.92 | ALDH1A1 (0.58) | LOXL2TAAR1SLC6A2SLC6A3IDO1 | |
| SCHEMBL5715396 | 0.84 | LOXL2 (0.55) | LOXL2IDO1KCNJ1KCNH2MEN1 | |
| SCHEMBL16449786 | 0.83 | KMT2A (0.49) | LOXL2IDO1KCNJ1KCNH2MEN1 | |
| SCHEMBL19938078 | 0.81 | LOXL2 (0.58) | LOXL2IDO1KCNJ1KCNH2MEN1 | |
| SCHEMBL8855359 | 0.81 | TSHR (0.55) | LOXL2IDO1KCNJ1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4297346-A | PSYCHOACTIVE DRUGS BONDED TO NEUROPEPTIDES | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1981-10-27 | — | — | US | claimed |
| US-4066658-A | RESOLUTION OF D,L-DEHYDROPROLINE | HOFFMANN-LA ROCHE INC. (US) | 1978-01-03 | — | — | US | claimed |
| CN-117357503-B | Use of p-hydroxyphenylacetamide in the treatment of psychotic disorders | 中国人民解放军军事科学院军事医学研究院 | 2024-03-08 | — | — | CN | disclosed |
| CN-117357503-A | Use of p-hydroxyphenylacetamide in the treatment of psychotic disorders | 中国人民解放军军事科学院军事医学研究院 | 2024-01-09 | — | — | CN | disclosed |
| US-11739089-B2 | Acetamido-phenyltetrazole derivatives and methods of using the same | ATHENEX, INC. (US) | 2023-08-29 | — | — | US | disclosed |
| US-20220106312-A1 | ACETAMIDO-PHENYLTETRAZOLE DERIVATIVES AND METHODS OF USING THE SAME | Health Hope Pharma Limited (HK) | 2022-04-07 | — | — | US | disclosed |
| US-10000555-B2 | Monomethylvaline compounds having phenylalanine side-chain modification at the C-terminus | SEATTLE GENETICS, INC. (US) | 2018-06-19 | — | — | US | disclosed |
| US-20180066007-A1 | Macrocyclic Compounds And Methods Of Making And Using The Same | BioVersys AG (CH) | 2018-03-08 | — | — | US | disclosed |
| US-8841263-B2 | Macrocyclic compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2014-09-23 | — | — | US | disclosed |
| US-20130123465-A1 | MONOMETHYLVALINE COMPOUNDS HAVING PHENYLALANINE SIDE-CHAIN MODIFICATIONS AT THE C-TERMINUS | SEATTLE GENETICS, INC. (US) | 2013-05-16 | — | — | US | disclosed |
| US-8343928-B2 | Monomethylvaline compounds having phenylalanine side-chain replacements at the C-terminus | SEATTLE GENETICS, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| WO-1998008502-A1 | SUBSTITUTED 1,2,3,4-TETRAHYDRO-2-DIBENZOFURANAMINES AND 2-AMINOCYCLOHEPTA[b]BENZOFURANS | ELI LILLY AND COMPANY (US) | 1998-03-05 | — | — | WO | disclosed |
| EP-0824917-A2 | Use of a serotonin 5-HTlf agonist in the manufacture of a medicament for treating or ameliorating the symptoms of common cold or allergic rhinitis | ELI LILLY AND COMPANY (US) | 1998-02-25 | — | — | EP | disclosed |
| US-5708187-A | MIGRANE HEADACHES | ELI LILLY AND COMPANY (US) | 1998-01-13 | — | — | US | disclosed |
| EP-0749962-A1 | 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta(7,6-B)indoles | ELI LILLY AND COMPANY (US) | 1996-12-27 | — | — | EP | disclosed |
| EP-0404146-B1 | Enantiomeric enrichment and stereoselective synthesis of chiral amines | CELGENE CORP (US) | 1996-03-20 | — | — | EP | disclosed |
| EP-0404146-A2 | Enantiomeric enrichment and stereoselective synthesis of chiral amines | CELGENE CORPORATION (US) | 1990-12-27 | — | — | EP | disclosed |
| EP-0371253-A2 | Method and reagents for detecting amphetamine and/or d-methamphetamine in biological samples | ABBOTT LABORATORIES (US) | 1990-06-06 | — | — | EP | disclosed |
| US-4297346-A | PSYCHOACTIVE DRUGS BONDED TO NEUROPEPTIDES | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1981-10-27 | — | — | US | disclosed |
| US-4066658-A | RESOLUTION OF D,L-DEHYDROPROLINE | HOFFMANN-LA ROCHE INC. (US) | 1978-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220106312-A1 | ACETAMIDO-PHENYLTETRAZOLE DERIVATIVES AND METHODS OF USING THE SAME | ABCB1, CYP3A5, CYP3A7 | LOXL2 4560/4885TAAR1 4319/4885SLC6A2 1004/4885 |
| US-20130123465-A1 | MONOMETHYLVALINE COMPOUNDS HAVING PHENYLALANINE SIDE-CHAIN MODIFICATIONS AT THE C-TERMINUS | MMAB, PTMS, DNPEP | LOXL2 2215/4885TAAR1 4174/4885SLC6A2 3436/4885 |
| US-20180066007-A1 | Macrocyclic Compounds And Methods Of Making And Using The Same | CCNO, PTGDR, CCNE1 | LOXL2 4490/4885TAAR1 3891/4885SLC6A2 2216/4885 |
| US-11739089-B2 | Acetamido-phenyltetrazole derivatives and methods of using the same | ABCB1, CYP3A5, CYP3A7 | LOXL2 4560/4885TAAR1 4319/4885SLC6A2 1004/4885 |
| US-10000555-B2 | Monomethylvaline compounds having phenylalanine side-chain modification at the C-terminus | PTMS, MMAB, DNPEP | LOXL2 2146/4885TAAR1 4189/4885SLC6A2 3422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.