Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 16/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | USP5 | P45974 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5354245 | 0.85 | USP2 (0.43) | CCR2USP2ALDH1A1MAPTALOX12 | |
| SCHEMBL5315276 | 0.80 | CCR2 (0.44) | CCR2 | |
| SCHEMBL5264818 | 0.80 | CCR2 (0.63) | CCR2ALDH1A1MAPT | |
| SCHEMBL5946915 | 0.80 | CCR2 (0.63) | CCR2ALDH1A1MAPT | |
| SCHEMBL5326187 | 0.78 | USP2 (0.41) | CCR2USP2ALDH1A1MAPTALOX12 | |
| SCHEMBL5324768 | 0.78 | CCR2 (0.49) | CCR2USP2ALDH1A1MAPTALOX12 | |
| SCHEMBL5324932 | 0.76 | CCR2 (0.47) | CCR2USP2ALDH1A1MAPTALOX12 | |
| SCHEMBL5322776 | 0.76 | CCR2 (0.46) | CCR2USP2ALDH1A1MAPTALOX12 | |
| SCHEMBL5389538 | 0.75 | CCR2 (0.73) | CCR2 | |
| SCHEMBL5947137 | 0.75 | CCR2 (0.73) | CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802602-A1 | SUBSTITUTED DIPIPERDINE CCR2 ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006036527-A1 | SUBSTITUTED DIPIPERDINE CCR2 ANTAGONISTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-04-06 | — | — | WO | disclosed |