Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 14/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264815 | 0.80 | CCR2 (0.44) | CCR2 | |
| SCHEMBL5315280 | 0.80 | CCR2 (0.64) | CCR2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5319191 | 0.78 | CCR1 (0.38) | CCR2DRD2CCR1 | |
| SCHEMBL5350435 | 0.76 | DRD2 (0.41) | CCR2DRD2CCR1 | |
| SCHEMBL5317370 | 0.75 | CCR2 (0.55) | CCR2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5322776 | 0.74 | CCR2 (0.46) | CCR2DRD2 | |
| SCHEMBL5323601 | 0.73 | CCR2 (0.48) | CCR2CYP2D6DRD2 | |
| SCHEMBL5318246 | 0.72 | CCR2 (0.70) | CCR2 | |
| SCHEMBL5325878 | 0.69 | CCR1 (0.44) | CCR2CCR1 | |
| SCHEMBL5320143 | 0.69 | CCR2 (0.71) | CCR2CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802602-A1 | SUBSTITUTED DIPIPERDINE CCR2 ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006036527-A1 | SUBSTITUTED DIPIPERDINE CCR2 ANTAGONISTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-04-06 | — | — | WO | disclosed |