Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMD14 | O00487 | 2/20 | 0.48 |
| ▸ | STAMBP | O95630 | 1/20 | 0.48 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 9/20 | 0.46 |
| ▸ | UBE2N | P61088 | 2/20 | 0.43 |
| ▸ | APAF1 | O14727 | 2/20 | 0.40 |
| ▸ | CASP6 | P55212 | 2/20 | 0.40 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 2/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.38 |
| ▸ | F3 | P13726 | 1/20 | 0.38 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL163182 | 0.90 | PSMD14 (0.56) | PSMD14STAMBPCOPS5RIPK1ACP1 | |
| SCHEMBL27599972 | 0.88 | PSMD14 (0.55) | PSMD14STAMBPCOPS5RIPK1ACP1 | |
| Hydrochloric Acid SCHEMBL14966721 | 0.88 | PSMD14 (0.55) | PSMD14STAMBPCOPS5RIPK1ACP1 | |
| Trifluoroacetic Acid SCHEMBL5265639 | 0.87 | PSMD14 (0.45) | PSMD14STAMBPCOPS5L3MBTL1PAX8 | |
| Formic Acid SCHEMBL30468936 | 0.84 | PSMD14 (0.51) | PSMD14STAMBPCOPS5RIPK1ACP1 | |
| Trifluoroacetic Acid SCHEMBL8360271 | 0.80 | MGAM (0.62) | PSMD14STAMBPCOPS5HPGDSMGAM | |
| Trifluoroacetic Acid SCHEMBL2268493 | 0.80 | KDM4E (0.55) | L3MBTL1UBE2NAPAF1CASP6CASP8 | |
| SCHEMBL124592 | 0.79 | MGAM (0.59) | PSMD14STAMBPCOPS5ACP1MGAM | |
| SCHEMBL30392839 | 0.79 | MGAM (0.59) | PSMD14STAMBPCOPS5ACP1MGAM | |
| Hydrochloric Acid SCHEMBL7010614 | 0.77 | MGAM (0.57) | PSMD14STAMBPCOPS5ACP1MGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1866305-A1 | 1,7-NAPHTHYRIDINES AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-12-19 | — | — | EP | claimed |
| WO-2006097340-A1 | 1,7-NAPHTHYRIDINES AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-09-21 | — | — | WO | claimed |
| EP-1866305-A1 | 1,7-NAPHTHYRIDINES AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006097340-A1 | 1,7-NAPHTHYRIDINES AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-09-21 | — | — | WO | disclosed |