Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CETP | P11597 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5268520 | 0.88 | ALDH1A1 (0.47) | SMN1; SMN2GAAKMT2AALDH1A1KDM4E | |
| SCHEMBL5267787 | 0.85 | NPC1 (0.44) | SMN1; SMN2GAAKMT2AALDH1A1KDM4E | |
| SCHEMBL2799869 | 0.85 | HPGD (0.46) | SMN1; SMN2GAAKMT2AALDH1A1KDM4E | |
| SCHEMBL4292756 | 0.84 | NPC1 (0.44) | SMN1; SMN2ALDH1A1KDM4EHPGDNPSR1 | |
| SCHEMBL5266880 | 0.82 | HPGD (0.59) | SMN1; SMN2GAAHPGDCETPHDAC3 | |
| SCHEMBL955574 | 0.80 | CCNA2 (0.62) | SMN1; SMN2GAAKMT2AALDH1A1KDM4E | |
| SCHEMBL8262998 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL5273437 | 0.79 | KDM4E (0.44) | SMN1; SMN2GAAKMT2AALDH1A1KDM4E | |
| SCHEMBL5269314 | 0.79 | LMNA (0.45) | SMN1; SMN2GAAKMT2AALDH1A1KDM4E | |
| SCHEMBL5269651 | 0.78 | HPGD (0.52) | SMN1; SMN2ALDH1A1HPGDNPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847531-A1 | PYRAZOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2007-10-24 | — | — | EP | disclosed |