Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.40 |
| ▸ | POLH | Q9Y253 | 5/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.40 |
| ▸ | TNKS | O95271 | 4/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.38 |
| ▸ | THRB | P10828 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.38 |
| ▸ | HPGD | P15428 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | IP6K2 | Q9UHH9 | 6/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL313143 | 0.74 | MEN1 (0.62) | POLHPDE4DMEN1KMT2ACYP3A4 | |
| SCHEMBL311509 | 0.74 | POLH (0.62) | PARP1POLHALOX5TNKSTNKS2 | |
| SCHEMBL312444 | 0.72 | CDK5 (0.54) | PARP1POLHTNKSTNKS2MEN1 | |
| SCHEMBL311223 | 0.72 | KDM4E (0.60) | PARP1POLHTNKSTNKS2MEN1 | |
| SCHEMBL5266744 | 0.72 | POLH (0.42) | PARP1POLHALOX5TNKSTNKS2 | |
| SCHEMBL312151 | 0.71 | CYP3A4 (0.59) | PARP1POLHTNKSTNKS2MEN1 | |
| SCHEMBL312113 | 0.71 | CYP3A4 (0.59) | PARP1POLHALOX5TNKSTNKS2 | |
| SCHEMBL5265130 | 0.71 | ALOX5 (0.40) | PARP1POLHALOX5TNKSTNKS2 | |
| SCHEMBL312584 | 0.64 | KDM4E (0.49) | PARP1POLHALOX5TNKSTNKS2 | |
| SCHEMBL5264726 | 0.64 | PARP1 (0.43) | PARP1POLHALOX5TNKSTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838296-A2 | FLAVANOIDS AND ISOFLAVANOIDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES | RESVERLOGIX CORP. (CA) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006045096-A2 | FLAVANOIDS AND ISOFLAVANOIDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES | RESVERLOGIX CORP. (CA) | 2006-04-27 | — | — | WO | disclosed |