Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLH | Q9Y253 | 5/20 | 0.42 |
| ▸ | TNKS | O95271 | 4/20 | 0.42 |
| ▸ | PARP1 | P09874 | 4/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 6/20 | 0.39 |
| ▸ | IP6K2 | Q9UHH9 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.39 |
| ▸ | THRB | P10828 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | BACE1 | P56817 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL311672 | 0.82 | CYP3A4 (0.46) | POLHTNKSPARP1TNKS2CYP3A4 | |
| SCHEMBL312346 | 0.81 | BACE1 (0.51) | POLHTNKSPARP1TNKS2CYP3A4 | |
| SCHEMBL312234 | 0.81 | POLH (0.50) | POLHTNKSPARP1TNKS2ALOX5 | |
| SCHEMBL311589 | 0.78 | CYP3A4 (0.49) | POLHTNKSPARP1TNKS2CYP3A4 | |
| SCHEMBL312658 | 0.75 | CYP3A4 (0.46) | POLHTNKSPARP1TNKS2CYP3A4 | |
| SCHEMBL5266563 | 0.72 | PARP1 (0.40) | POLHTNKSPARP1TNKS2ALOX5 | |
| SCHEMBL5265130 | 0.72 | ALOX5 (0.40) | POLHTNKSPARP1TNKS2ALOX5 | |
| SCHEMBL312179 | 0.65 | MAOB (0.39) | KDM4EHPGDHSD17B10SMN1; SMN2CYP2C9 | |
| SCHEMBL312751 | 0.65 | MAPT (0.59) | POLHTNKSPARP1TNKS2ALOX5 | |
| SCHEMBL311921 | 0.65 | CYP3A4 (0.62) | TNKSCYP3A4KDM4EHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838296-A2 | FLAVANOIDS AND ISOFLAVANOIDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES | RESVERLOGIX CORP. (CA) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006045096-A2 | FLAVANOIDS AND ISOFLAVANOIDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES | RESVERLOGIX CORP. (CA) | 2006-04-27 | — | — | WO | disclosed |