Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | SOAT2 | O75908 | 2/20 | 0.42 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 8/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27678180 | 0.87 | OXTR (0.44) | CYP2C9CYP2C19SOAT2SOAT1RAB9A | |
| SCHEMBL27676108 | 0.86 | SOAT2 (0.52) | CYP2C9CYP2C19SOAT2SOAT1RAB9A | |
| SCHEMBL28053394 | 0.84 | TP53 (0.44) | CYP2C19SOAT2SOAT1RAB9ANPC1 | |
| SCHEMBL27742973 | 0.83 | KDM4E (0.39) | SOAT2SOAT1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL27728421 | 0.82 | TLR7 (0.41) | SOAT2SOAT1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9453146 | 0.82 | SOAT1 (0.58) | CYP2C9CYP2C19SOAT2SOAT1RAB9A | |
| SCHEMBL28766878 | 0.81 | HTT (0.46) | SMN1; SMN2ALDH1A1KDM4EMEN1ALOX12 | |
| SCHEMBL11086699 | 0.81 | SOAT1 (0.60) | CYP2C9CYP2C19SOAT2SOAT1RAB9A | |
| SCHEMBL27707912 | 0.80 | HPGD (0.55) | CYP2C9CYP2C19SOAT2SOAT1SMN1; SMN2 | |
| SCHEMBL2247863 | 0.79 | CYP2D6 (0.41) | CYP2C9CYP2C19SMN1; SMN2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101759645-B | P38 inhibitors and methods of use thereof | ARRAY BIOPHARMA INC | 2014-06-25 | — | — | CN | disclosed |
| CN-103483338-A | Triazolopyridine derivatives as p38 map kinase inhibitors | CHIESI FARMA SPA | 2014-01-01 | — | — | CN | disclosed |
| CN-102395586-A | Triazolopyridine Derivatives as P38MAP Kinase Inhibitors | THERAPEUTICS INFLAMMATION LTD | 2012-03-28 | — | — | CN | disclosed |
| CN-101759645-A | P38 inhibitors and methods of use thereof | ARRAY BIOPHARMA INC | 2010-06-30 | — | — | CN | disclosed |
| CN-100579976-C | p38 inhibitors and methods of their use | ARRAY BIOPHARMA INC | 2010-01-13 | — | — | CN | disclosed |
| CN-101296922-A | Kinase inhibitors | LILLY CO ELI (US) | 2008-10-29 | — | — | CN | disclosed |
| CN-101098868-A | Substituted indoles, compositions containing them, method for the production thereof and their use | AVENTIS PHARMA SA (FR) | 2008-01-02 | — | — | CN | disclosed |
| EP-1841762-A1 | SUBSTITUTED INDOLES, COMPOSITIONS CONTAINING THEM, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE | Aventis Pharma S.A. (FR) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006061493-A1 | SUBSTITUTED INDOLES, COMPOSITIONS CONTAINING THEM, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE | AVENTIS PHARMA S.A. (FR) | 2006-06-15 | — | — | WO | disclosed |
| CN-1784396-A | p38 inhibitors and methods of their use | ARRAY BIOPHARMA INC (US) | 2006-06-07 | — | — | CN | disclosed |