Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.48 |
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL389003 | 0.87 | FAAH (0.53) | FAAHGPR119NAMPTKDM4EPKM | |
| SCHEMBL389281 | 0.84 | GPR119 (0.47) | FAAHGPR119 | |
| SCHEMBL3865846 | 0.83 | GPR119 (0.50) | FAAHGPR119NAMPTKDM4EPKM | |
| SCHEMBL388825 | 0.79 | KDM4E (0.46) | FAAHGPR119NAMPTKDM4EPKM | |
| SCHEMBL389652 | 0.79 | FAAH (0.55) | FAAHGPR119KDM4EPKMKEAP1 | |
| SCHEMBL391706 | 0.78 | GPR119 (0.71) | FAAHGPR119 | |
| SCHEMBL389218 | 0.78 | GPR119 (0.54) | FAAHGPR119KDM4EPKMKEAP1 | |
| SCHEMBL391806 | 0.77 | FAAH (0.65) | FAAHGPR119KDM4EPKMKEAP1 | |
| SCHEMBL6949682 | 0.76 | GPR119 (0.47) | FAAHGPR119KDM4EPKMKEAP1 | |
| SCHEMBL27035706 | 0.76 | GPR119 (0.53) | FAAHGPR119KDM4EPKMKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838311-A1 | G-PROTEIN COUPLED RECEPTOR (GPR116) AGONISTS AND USE THEREOF FOR TREATING OBESITY AND DIABETES | Prosidion Limited (GB) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006067531-A1 | G-PROTEIN COUPLED RECEPTOR (GPR116) AGONISTS AND USE THEREOF FOR TREATING OBESITY AND DIABETES | PROSIDION LTD (GB) | 2006-06-29 | — | — | WO | disclosed |