Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.70 |
| ▸ | HTR1A | P08908 | 1/20 | 0.67 |
| ▸ | DRD2 | P14416 | 1/20 | 0.67 |
| ▸ | DRD4 | P21917 | 1/20 | 0.67 |
| ▸ | HTR1D | P28221 | 1/20 | 0.67 |
| ▸ | HTR1B | P28222 | 1/20 | 0.67 |
| ▸ | HTR1F | P30939 | 1/20 | 0.67 |
| ▸ | HTR7 | P34969 | 1/20 | 0.67 |
| ▸ | DRD3 | P35462 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.54 |
| ▸ | TUBB | P07437 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3280964 | 0.91 | EGFR (0.57) | HTR6HTR1ADRD2DRD4HTR1D | |
| SCHEMBL9094606 | 0.88 | HTR6 (0.73) | HTR6HTR1ADRD2DRD4HTR1D | |
| SCHEMBL2204353 | 0.86 | HTR6 (0.74) | HTR6HTR1ADRD2DRD4HTR1D | |
| SCHEMBL2204865 | 0.85 | HTR6 (0.76) | HTR6HTR1ADRD2DRD4HTR1D | |
| SCHEMBL3033159 | 0.84 | HTR6 (0.80) | HTR6HTR1ADRD2DRD4HTR1D | |
| SCHEMBL9449326 | 0.82 | MCL1 (0.63) | HTR6HTR1ADRD2DRD4HTR1D | |
| SCHEMBL1486947 | 0.82 | HTR6 (1.00) | HTR6HTR1ADRD2DRD4HTR1D | |
| SCHEMBL7380686 | 0.82 | HTR6 (0.68) | HTR6HTR1ADRD2DRD4HTR1D | |
| SCHEMBL9154720 | 0.82 | KDM4E (0.61) | HTR6ALDH1A1MAPTTSHRKDM4E | |
| SCHEMBL3029129 | 0.82 | HTR6 (0.75) | HTR6HTR1ADRD2DRD4HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1852420-B1 | Indole compounds for treating respiratory disorders | ONO PHARMACEUTICAL CO (JP) | 2012-10-17 | — | — | EP | disclosed |
| EP-1852420-A1 | INDOLE COMPOUND AND USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-11-07 | — | — | EP | disclosed |