Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.80 |
| ▸ | HTR1A | P08908 | 1/20 | 0.76 |
| ▸ | DRD2 | P14416 | 1/20 | 0.76 |
| ▸ | DRD4 | P21917 | 1/20 | 0.76 |
| ▸ | HTR1D | P28221 | 1/20 | 0.76 |
| ▸ | HTR1B | P28222 | 1/20 | 0.76 |
| ▸ | HTR1F | P30939 | 1/20 | 0.76 |
| ▸ | HTR7 | P34969 | 1/20 | 0.76 |
| ▸ | DRD3 | P35462 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.61 |
| ▸ | TUBB | P07437 | 2/20 | 0.61 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.61 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.61 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.61 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.61 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1486947 | 0.89 | HTR6 (1.00) | HTR6HTR1ADRD2DRD4HTR1D | |
| SCHEMBL2204865 | 0.89 | HTR6 (0.76) | HTR6HTR1ADRD2DRD4HTR1D | |
| SCHEMBL3029129 | 0.88 | HTR6 (0.75) | HTR6HTR1ADRD2DRD4HTR1D | |
| SCHEMBL2204353 | 0.88 | HTR6 (0.74) | HTR6HTR1ADRD2DRD4HTR1D | |
| Hydrochloric Acid SCHEMBL1486945 | 0.88 | HTR6 (0.97) | HTR6HTR1ADRD2DRD4HTR1D | |
| SCHEMBL7381366 | 0.88 | HTR6 (0.74) | HTR6HTR1ADRD2DRD4HTR1D | |
| SCHEMBL3195026 | 0.87 | HTR6 (0.73) | HTR6HTR1ADRD2DRD4HTR1D | |
| SCHEMBL9094606 | 0.87 | HTR6 (0.73) | HTR6HTR1ADRD2DRD4HTR1D | |
| SCHEMBL7380686 | 0.86 | HTR6 (0.68) | HTR6HTR1ADRD2DRD4HTR1D | |
| SCHEMBL9686881 | 0.86 | HTR6 (0.71) | HTR6HTR1ADRD2DRD4HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304419-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2012-11-06 | — | — | US | disclosed |
| US-20100216746-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-08-26 | — | — | US | disclosed |
| EP-2166856-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154271-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216746-A1 | CHEMICAL COMPOUNDS | SAMHD1, POLRMT, NUDT1 | HTR6 3664/4885HTR1A 4178/4885DRD2 2775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.