Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.34 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 3/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | UBE2N | P61088 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16809588 | 0.80 | L3MBTL1 (0.49) | L3MBTL1RAPGEF4PKMKDM4ETSHR | |
| SCHEMBL13494114 | 0.77 | L3MBTL1 (0.50) | L3MBTL1RAPGEF4PKMTSHRHTT | |
| SCHEMBL260617 | 0.76 | L3MBTL1 (0.55) | L3MBTL1RAPGEF4PKMKDM4ETSHR | |
| SCHEMBL4067920 | 0.76 | L3MBTL1 (0.44) | L3MBTL1RAPGEF4PKMKDM4ETSHR | |
| SCHEMBL13769391 | 0.76 | L3MBTL1 (0.46) | L3MBTL1RAPGEF4KDM4ETSHRNOD1 | |
| SCHEMBL5411086 | 0.74 | L3MBTL1 (0.50) | L3MBTL1RAPGEF4PKMKDM4ETSHR | |
| SCHEMBL24262373 | 0.74 | L3MBTL1 (0.43) | L3MBTL1RAPGEF4KDM4ETSHRHSD17B10 | |
| SCHEMBL24262374 | 0.74 | L3MBTL1 (0.43) | L3MBTL1RAPGEF4KDM4ETSHRHSD17B10 | |
| SCHEMBL30575111 | 0.74 | L3MBTL1 (0.43) | L3MBTL1RAPGEF4KDM4ETSHRHSD17B10 | |
| SCHEMBL4075074 | 0.74 | L3MBTL1 (0.52) | L3MBTL1RAPGEF4PKMKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844050-A1 | PYRROLOPYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASE | Vertex Pharmaceuticals, Inc. (US) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006096270-A1 | PYRROLOPYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-09-14 | — | — | WO | disclosed |