Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5272192 | 0.91 | KDM4E (0.41) | KDM4EALDH1A1RXFP1HSD17B10HPGD | |
| SCHEMBL5269397 | 0.90 | KDM4E (0.36) | KDM4EALDH1A1RXFP1HSD17B10HPGD | |
| SCHEMBL5273186 | 0.89 | NPC1 (0.42) | KDM4EALDH1A1RXFP1HSD17B10HPGD | |
| SCHEMBL5271977 | 0.88 | FAAH (0.40) | KDM4EALDH1A1RXFP1HSD17B10HPGD | |
| SCHEMBL5271030 | 0.88 | FAAH (0.38) | KDM4EALDH1A1RXFP1HSD17B10HPGD | |
| SCHEMBL5269620 | 0.87 | KDM4E (0.38) | KDM4EALDH1A1RXFP1HSD17B10HPGD | |
| SCHEMBL5267665 | 0.87 | MAPK1 (0.39) | NPC1RAB9ATP53MAPK1 | |
| SCHEMBL5269079 | 0.86 | KDM4E (0.38) | KDM4EALDH1A1RXFP1HSD17B10HPGD | |
| SCHEMBL5269494 | 0.85 | NR1H4 (0.41) | KDM4EALDH1A1HSD17B10ALOX15KMT2A | |
| SCHEMBL5274086 | 0.84 | AKT1 (0.39) | KDM4EALDH1A1HSD17B10HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1845098-A1 | Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands | FERRER INTERNACIONAL, S.A. (ES) | 2007-10-17 | — | — | EP | claimed |
| EP-1845098-A1 | Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands | FERRER INTERNACIONAL, S.A. (ES) | 2007-10-17 | — | — | EP | disclosed |