Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5273186 | 0.93 | NPC1 (0.42) | KDM4EALDH1A1HSD17B10HPGDNPC1 | |
| SCHEMBL5271977 | 0.92 | FAAH (0.40) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL5271030 | 0.92 | FAAH (0.38) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL5269602 | 0.91 | KDM4E (0.37) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL5269494 | 0.90 | NR1H4 (0.41) | KDM4EALDH1A1HSD17B10LRRK2NPC1 | |
| SCHEMBL5267665 | 0.90 | MAPK1 (0.39) | NPC1RAB9AMAPK1LMNANR1H4 | |
| SCHEMBL5269397 | 0.89 | KDM4E (0.36) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL5269079 | 0.89 | KDM4E (0.38) | KDM4EALDH1A1HSD17B10HPGDNPC1 | |
| SCHEMBL5274086 | 0.88 | AKT1 (0.39) | KDM4EALDH1A1HSD17B10HPGDNOTUM | |
| SCHEMBL5269620 | 0.87 | KDM4E (0.38) | KDM4EALDH1A1HSD17B10HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1845098-A1 | Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands | FERRER INTERNACIONAL, S.A. (ES) | 2007-10-17 | — | — | EP | claimed |
| EP-1845098-A1 | Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands | FERRER INTERNACIONAL, S.A. (ES) | 2007-10-17 | — | — | EP | disclosed |