Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5269079 | 0.93 | KDM4E (0.38) | NPC1RAB9AALDH1A1MAPK1HPGD | |
| SCHEMBL5272192 | 0.93 | KDM4E (0.41) | NPC1RAB9AALDH1A1MAPK1HPGD | |
| SCHEMBL5267665 | 0.92 | MAPK1 (0.39) | NPC1RAB9AMAPK1SLC2A2 | |
| SCHEMBL5269397 | 0.91 | KDM4E (0.36) | NPC1RAB9AALDH1A1MAPK1HPGD | |
| SCHEMBL5271977 | 0.90 | FAAH (0.40) | NPC1RAB9AALDH1A1MAPK1HPGD | |
| SCHEMBL5271030 | 0.90 | FAAH (0.38) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL5269602 | 0.89 | KDM4E (0.37) | NPC1RAB9AALDH1A1MAPK1HPGD | |
| SCHEMBL5274086 | 0.88 | AKT1 (0.39) | NPC1RAB9AALDH1A1MAPK1HPGD | |
| SCHEMBL5269494 | 0.87 | NR1H4 (0.41) | NPC1RAB9AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL5269620 | 0.85 | KDM4E (0.38) | ALDH1A1HPGDKDM4EHSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1845098-A1 | Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands | FERRER INTERNACIONAL, S.A. (ES) | 2007-10-17 | — | — | EP | claimed |
| WO-2007110438-A1 | IMIDAZO [1,2 -B] PYRIDAZINES, THEIR PROCESSES OF PREPARATION AND THEIR USE AS GABA RECEPTOR LIGANDS | FERRER INTERNACIONAL, S.A. (ES) | 2007-10-04 | — | — | WO | claimed |
| EP-1845098-A1 | Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands | FERRER INTERNACIONAL, S.A. (ES) | 2007-10-17 | — | — | EP | disclosed |
| WO-2007110438-A1 | IMIDAZO [1,2 -B] PYRIDAZINES, THEIR PROCESSES OF PREPARATION AND THEIR USE AS GABA RECEPTOR LIGANDS | FERRER INTERNACIONAL, S.A. (ES) | 2007-10-04 | — | — | WO | disclosed |