Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STS | P08842 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1659344 | 0.80 | HSD11B1 (0.51) | STSHSD11B1HRH3ESR1CYP3A4 | |
| SCHEMBL1656552 | 0.79 | HSD11B1 (0.53) | STSHSD11B1HRH3ESR1CYP3A4 | |
| SCHEMBL9747655 | 0.75 | STS (0.47) | STSHRH3ESR1HDAC3HDAC6 | |
| SCHEMBL2962921 | 0.74 | STS (0.47) | STSHRH3ESR1CYP3A4LMNA | |
| SCHEMBL5273029 | 0.73 | HSD11B1 (0.55) | STSHSD11B1HRH3ESR1CYP3A4 | |
| SCHEMBL13216959 | 0.71 | STS (0.51) | STSHSD11B1HRH3ESR1CYP3A4 | |
| SCHEMBL27339223 | 0.70 | AR (0.47) | STSESR1CYP3A4LMNAPGR | |
| SCHEMBL13216951 | 0.64 | HSD11B1 (0.52) | STSHSD11B1HRH3ESR1CYP3A4 | |
| SCHEMBL8081744 | 0.64 | HSD11B1 (0.52) | STSHSD11B1HRH3ESR1CYP3A4 | |
| SCHEMBL6462357 | 0.63 | STS (0.54) | STSHRH3ESR1CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847548-A2 | Novel anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use | Sri International (US) | 2007-10-24 | — | — | EP | disclosed |