Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5241937 | 0.88 | BCHE (0.44) | NOX1MAPTLMNAMAPK1TDP1 | |
| SCHEMBL5243732 | 0.86 | CYP3A4 (0.46) | MAPTLMNAMAPK1TDP1CYP2D6 | |
| SCHEMBL5243083 | 0.78 | KMT2A (0.49) | CYP2D6CYP1A2CYP3A4TSHRCYP2C19 | |
| SCHEMBL5468076 | 0.76 | CYP3A4 (0.48) | NOX1MAPTLMNAMAPK1TDP1 | |
| SCHEMBL5280780 | 0.76 | BCHE (0.52) | MAPTLMNACYP2D6CYP1A2CYP3A4 | |
| SCHEMBL5278993 | 0.75 | BCHE (0.45) | NOX1MAPTLMNAMAPK1TDP1 | |
| SCHEMBL5456545 | 0.74 | CYP3A4 (0.48) | NOX1MAPTLMNAMAPK1TDP1 | |
| SCHEMBL5467983 | 0.74 | CYP3A4 (0.48) | NOX1MAPTLMNAMAPK1TDP1 | |
| SCHEMBL5350976 | 0.74 | KMT2A (0.55) | LMNACYP1A2CYP3A4TSHRCYP2C19 | |
| SCHEMBL30725912 | 0.72 | NOX1 (0.73) | NOX1MAPTLMNAMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833797-A1 | AZACYCLIC COMPOUNDS AS INHBITORS OF SENSORY NEURONE SPECIFIC CHANNELS (SNS) | VERNALIS (R&D) LTD (GB) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006082354-A1 | AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC CHANNELS ( SNS ) | VERNALIS (R & D) LIMITED (GB) | 2006-08-10 | — | — | WO | disclosed |