Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5280780 | 0.93 | BCHE (0.52) | KMT2AALDH1A1CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL5241937 | 0.92 | BCHE (0.44) | KMT2ANPC1POLBSMN1; SMN2HCRTR1 | |
| SCHEMBL5350976 | 0.91 | KMT2A (0.55) | KMT2AALDH1A1CYP3A4CYP1A2TSHR | |
| SCHEMBL5243272 | 0.86 | SMN1; SMN2 (0.52) | KMT2ANPC1POLBSMN1; SMN2HCRTR1 | |
| SCHEMBL5334834 | 0.82 | SMN1; SMN2 (0.59) | KMT2ANPC1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL5241484 | 0.80 | BCHE (0.47) | KMT2ASMN1; SMN2ALDH1A1USP2ALOX15 | |
| SCHEMBL5466400 | 0.79 | ALDH1A1 (0.56) | KMT2APOLBSMN1; SMN2ALDH1A1USP2 | |
| SCHEMBL5272020 | 0.78 | NOX1 (0.48) | KMT2AALDH1A1USP2ALOX15CYP3A4 | |
| SCHEMBL5243732 | 0.77 | CYP3A4 (0.46) | KMT2ANPC1SMN1; SMN2ALDH1A1USP2 | |
| SCHEMBL5289084 | 0.77 | SMN1; SMN2 (0.61) | KMT2ANPC1POLBSMN1; SMN2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833797-A1 | AZACYCLIC COMPOUNDS AS INHBITORS OF SENSORY NEURONE SPECIFIC CHANNELS (SNS) | VERNALIS (R&D) LTD (GB) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006082354-A1 | AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC CHANNELS ( SNS ) | VERNALIS (R & D) LIMITED (GB) | 2006-08-10 | — | — | WO | disclosed |