Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 3/20 | 0.45 |
| ▸ | ACHE | P22303 | 3/20 | 0.45 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5241484 | 0.92 | BCHE (0.47) | BCHEACHEMAPTLMNACYP3A4 | |
| SCHEMBL5242793 | 0.89 | BCHE (0.54) | BCHEACHEMAPTLMNAALDH1A1 | |
| SCHEMBL5279427 | 0.87 | CYP3A4 (0.41) | BCHEACHEMAPTLMNACYP3A4 | |
| SCHEMBL5288756 | 0.86 | MEN1 (0.54) | LMNACYP3A4CYP2D6CYP1A2TSHR | |
| SCHEMBL5241937 | 0.83 | BCHE (0.44) | BCHEACHENOX1MAPTLMNA | |
| SCHEMBL5456545 | 0.82 | CYP3A4 (0.48) | BCHEACHENOX1MAPTLMNA | |
| SCHEMBL5276265 | 0.78 | MCL1 (0.42) | LMNAMAPK1TSHRMCL1ALDH1A1 | |
| SCHEMBL5467983 | 0.75 | CYP3A4 (0.48) | BCHEACHENOX1MAPTLMNA | |
| SCHEMBL5272020 | 0.75 | NOX1 (0.48) | NOX1MAPTLMNAMAPK1TDP1 | |
| SCHEMBL5243083 | 0.73 | KMT2A (0.49) | BCHEACHECYP3A4CYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833797-A1 | AZACYCLIC COMPOUNDS AS INHBITORS OF SENSORY NEURONE SPECIFIC CHANNELS (SNS) | VERNALIS (R&D) LTD (GB) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006082354-A1 | AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC CHANNELS ( SNS ) | VERNALIS (R & D) LIMITED (GB) | 2006-08-10 | — | — | WO | disclosed |