Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5243083 | 0.91 | KMT2A (0.49) | KMT2AALDH1A1TSHRCYP1A2CYP3A4 | |
| SCHEMBL5280780 | 0.87 | BCHE (0.52) | KMT2AMEN1LMNAKDM4EALDH1A1 | |
| SCHEMBL5241937 | 0.87 | BCHE (0.44) | KMT2ALMNAALDH1A1TSHRCYP1A2 | |
| SCHEMBL5288756 | 0.83 | MEN1 (0.54) | KMT2AMEN1GAAHTTNPSR1 | |
| SCHEMBL5461510 | 0.83 | MEN1 (0.64) | KMT2AMEN1GAAHTTNPSR1 | |
| SCHEMBL5243272 | 0.78 | SMN1; SMN2 (0.52) | KMT2AGAAHTTNPSR1HPGD | |
| SCHEMBL5454426 | 0.78 | MEN1 (0.61) | KMT2AMEN1GAAHTTNPSR1 | |
| SCHEMBL5334834 | 0.75 | SMN1; SMN2 (0.59) | KMT2AMEN1GAAHTTNPSR1 | |
| SCHEMBL5272020 | 0.74 | NOX1 (0.48) | KMT2AMEN1GAAHTTLMNA | |
| SCHEMBL5243732 | 0.73 | CYP3A4 (0.46) | KMT2AMEN1GAAHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833797-A1 | AZACYCLIC COMPOUNDS AS INHBITORS OF SENSORY NEURONE SPECIFIC CHANNELS (SNS) | VERNALIS (R&D) LTD (GB) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006082354-A1 | AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC CHANNELS ( SNS ) | VERNALIS (R & D) LIMITED (GB) | 2006-08-10 | — | — | WO | disclosed |