Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28584478 | 0.82 | HTR2A (0.41) | HTR2BHTR2AHTR2CLMNA | |
| SCHEMBL477584 | 0.82 | CYP3A4 (0.41) | ALDH1A1HTR2BCYP3A4CHRM1ALOX15 | |
| SCHEMBL29403294 | 0.82 | CYP3A4 (0.41) | ALDH1A1HTR2BCYP3A4CHRM1ALOX15 | |
| SCHEMBL4448667 | 0.81 | ALDH1A1 (0.36) | ALDH1A1CYP3A4 | |
| Water SCHEMBL28514557 | 0.78 | CYP3A4 (0.39) | ALDH1A1HTR2BCYP3A4CHRM1ALOX15 | |
| SCHEMBL20137111 | 0.77 | CYP3A4 (0.37) | ALDH1A1HTR2BCYP3A4CHRM1ALOX15 | |
| SCHEMBL2892194 | 0.77 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL19472050 | 0.77 | CYP3A4 (0.38) | ALDH1A1CYP3A4 | |
| SCHEMBL13235165 | 0.77 | ALDH1A1 (0.33) | ALDH1A1HTR2BHTR2AHTR2C | |
| SCHEMBL31469117 | 0.77 | ALDH1A1 (0.33) | ALDH1A1HTR2BHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3212642-B1 | AMIDE SUBSTITUTED THIAZOLES AS MODULATORS OF RORGAMMAT | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-30 | — | — | EP | disclosed |
| US-9926337-B2 | Substituted asymmetric ureas as modulators of ghrelin receptor activity | HELSINN HEALTHCARE SA (CH) | 2018-03-27 | — | — | US | disclosed |
| US-20170145038-A1 | SUBSTITUTED ASYMMETRIC UREAS AND MEDICAL USES THEREOF | HELSINN HEALTHCARE SA (CH) | 2017-05-25 | — | — | US | disclosed |
| US-9546157-B2 | Asymmetric piperidinyl-substituted ureas as medicines | HELSINN HEALTHCARE SA (CH) | 2017-01-17 | — | — | US | disclosed |
| US-20150252021-A1 | p-Substituted Asymmetric Ureas and Medical Uses Thereof | HELSINN HEALTHCARE SA (CH) | 2015-09-10 | — | — | US | disclosed |
| EP-1841740-A1 | 3,4,(5)-SUBSTITUTED TETRAHVDROPYRIDINES | Novartis AG (CH) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006074924-A1 | 3,4,(5)-SUBSTITUTED TETRAHVDROPYRIDINES | NOVARTIS AG (CH) | 2006-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150252021-A1 | p-Substituted Asymmetric Ureas and Medical Uses Thereof | UTS2R, GIPR, GPR119 | ALDH1A1 2353/4885HTR2B 549/4885HTR2A 410/4885 |
| US-20170145038-A1 | SUBSTITUTED ASYMMETRIC UREAS AND MEDICAL USES THEREOF | UTS2R, GHSR, GPR119 | ALDH1A1 1977/4885HTR2B 545/4885HTR2A 481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.