Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | TPMT | P51580 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8427155 | 0.82 | KMT2A (0.54) | KMT2ACYP1A2IMPDH2ALDH1A1KDM4E | |
| SCHEMBL7465002 | 0.82 | ALDH1A1 (0.42) | KMT2ACYP1A2IMPDH2ALDH1A1GAA | |
| SCHEMBL5275798 | 0.81 | IMPDH2 (0.36) | KMT2AIMPDH2ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4619369 | 0.79 | KMT2A (0.41) | KMT2ACYP1A2IMPDH2ALDH1A1KDM4E | |
| SCHEMBL14992760 | 0.78 | SMN1; SMN2 (0.35) | KMT2AIMPDH2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL3759267 | 0.77 | ALDH1A1 (0.44) | KMT2AALDH1A1KDM4EGAASMN1; SMN2 | |
| SCHEMBL4835517 | 0.76 | SLC6A2 (0.47) | KMT2ACYP1A2GAACYP2D6SMN1; SMN2 | |
| SCHEMBL5274054 | 0.76 | TAAR1 (0.53) | CYP1A2 | |
| SCHEMBL5271915 | 0.76 | KMT2A (0.44) | KMT2ACMA1CYP1A2ALDH1A1KDM4E | |
| SCHEMBL9953163 | 0.76 | IMPDH2 (0.37) | KMT2ACYP1A2IMPDH2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856075-A1 | SUBSTITUTED ARYLAMINE COMPOUNDS AND THEIR USE AS 5-HT6 MODULATORS | Epix Delaware, Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006081332-A1 | SUBSTITUTED ARYLAMINE COMPOUNDS AND THEIR USE AS 5-HT6 MODULATORS | EPIX DELAWARE, INC. (US) | 2006-08-03 | — | — | WO | disclosed |