Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | KRAS | P01116 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5275798 | 0.84 | IMPDH2 (0.36) | ALDH1A1MEN1POLBHPGDKMT2A | |
| SCHEMBL9886154 | 0.82 | PTGS2 (0.42) | ALDH1A1MEN1POLBHPGDKMT2A | |
| SCHEMBL5273699 | 0.82 | KMT2A (0.38) | ALDH1A1MEN1POLBHPGDKMT2A | |
| SCHEMBL21823537 | 0.82 | ALDH1A1 (0.35) | ALDH1A1MEN1POLBHPGDKMT2A | |
| SCHEMBL7494750 | 0.81 | CYP3A4 (0.49) | ALDH1A1MEN1POLBHPGDKMT2A | |
| SCHEMBL2467570 | 0.79 | DBH (0.41) | ALDH1A1TUBB1HTR2A | |
| SCHEMBL1940273 | 0.77 | MAPT (0.46) | ALDH1A1MEN1POLBHPGDKMT2A | |
| SCHEMBL3488489 | 0.77 | ALDH1A1 (0.35) | ALDH1A1MEN1POLBHPGDKMT2A | |
| SCHEMBL18606046 | 0.77 | HTR2A (0.41) | ALDH1A1MEN1POLBHPGDKMT2A | |
| SCHEMBL1942011 | 0.77 | ALDH1A1 (0.35) | ALDH1A1MEN1POLBHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1175400-A1 | RENIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000064873-A1 | RENIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-11-02 | — | — | WO | disclosed |