Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | RORC | P51449 | 5/20 | 0.33 |
| ▸ | CCKBR | P32239 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | CASR | P41180 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | ACE | P12821 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aseripide SCHEMBL29387471 | 1.00 | PTGS2 (0.36) | PTGS2RORCCCKBRIDO1CYP1A2 | |
| Aseripide SCHEMBL4096800 | 1.00 | PTGS2 (0.36) | PTGS2RORCCCKBRIDO1CYP1A2 | |
| Aseripide SCHEMBL4096803 | 1.00 | PTGS2 (0.36) | PTGS2RORCCCKBRIDO1CYP1A2 | |
| SCHEMBL8870912 | 0.95 | PTGS2 (0.36) | PTGS2RORCCCKBRIDO1CYP1A2 | |
| SCHEMBL8870781 | 0.93 | IDO1 (0.34) | RORCCCKBRIDO1CYP1A2CYP2C19 | |
| SCHEMBL8870811 | 0.93 | IDO1 (0.34) | RORCCCKBRIDO1CYP1A2CYP2C19 | |
| SCHEMBL8870784 | 0.93 | IDO1 (0.34) | RORCCCKBRIDO1CYP1A2CYP2C19 | |
| SCHEMBL8870373 | 0.92 | BACE1 (0.34) | RORC | |
| SCHEMBL8870107 | 0.90 | MEN1 (0.36) | PTGS2RORCCCKBRCYP1A2CYP2C19 | |
| SCHEMBL8870841 | 0.88 | CASR (0.36) | CCKBRCYP1A2CYP2C19CASRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0879054-B1 | APPLICATION OF PYRROLIDINE DERIVATIVES TO THE PREPARATION OF MEDICAMENTS INTENDED TO THE TREATMENT OF DRUG ABUSE | AVENTIS PHARMA SA (FR) | 2007-11-28 | — | — | EP | claimed |
| EP-0828486-B1 | USE OF PYRROLIDINE DERIVATIVES FOR TREATING ALCOHOLISM | AVENTIS PHARMA SA (FR) | 2002-09-18 | — | — | EP | claimed |
| US-6150387-A | Heterocyclic carboxamide compounds effective in the treatment of drug abuse | RHONE-POULENC RORER S.A. (FR) | 2000-11-21 | — | — | US | claimed |
| US-6150387-A | Heterocyclic carboxamide compounds effective in the treatment of drug abuse | RHONE-POULENC RORER S.A. (FR) | 2000-11-21 | — | — | US | disclosed |
| US-5610144-A | CHOLECYSTOKININ OR GASTRIN ANTAGONISTS; NERVOUS SYSTEM AND GASTROINTESTINAL DISORDERS | RHONE-POULENC RORER S.A. (FR) | 1997-03-11 | — | — | US | disclosed |