Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | PLAT | P00750 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 6/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL9536875 | 0.88 | ALOX5 (0.39) | LMNAESR1ESR2CYP3A4CYP2C9 | |
| Acetic Acid SCHEMBL2479593 | 0.88 | — | — | |
| SCHEMBL6846518 | 0.88 | PLG (0.37) | PLGPLATLMNAESR1ESR2 | |
| SCHEMBL4610 | 0.86 | — | — | |
| SCHEMBL1316560 | 0.86 | ESR2 (0.46) | ESR1ESR2CYP3A4CYP2C9TDP1 | |
| SCHEMBL2267415 | 0.86 | ESR2 (0.46) | ESR1ESR2CYP3A4CYP2C9TDP1 | |
| SCHEMBL297828 | 0.86 | ESR2 (0.46) | ESR1ESR2CYP3A4CYP2C9TDP1 | |
| SCHEMBL27912 | 0.86 | ESR2 (0.46) | ESR1ESR2CYP3A4CYP2C9TDP1 | |
| SCHEMBL130642 | 0.86 | ESR2 (0.46) | ESR1ESR2CYP3A4CYP2C9TDP1 | |
| Bicarbonate SCHEMBL7565580 | 0.85 | LMNA (0.42) | LMNAALOX5CYP2D6CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115594811-A | Polyurethane fabric resin for weather-resistant synthetic leather and preparation method thereof | 广东大盈新材料科技有限公司（CN） | 2023-01-13 | — | — | CN | claimed |
| CN-109791381-B | Electrophotographic photoreceptor, and electrophotographic process cartridge and image forming apparatus containing the same | 三菱化学株式会社 | 2023-03-10 | — | — | CN | disclosed |
| CN-115594811-A | Polyurethane fabric resin for weather-resistant synthetic leather and preparation method thereof | 广东大盈新材料科技有限公司（CN） | 2023-01-13 | — | — | CN | disclosed |
| CN-115210424-A | Resin composition for moisture-permeable waterproof fabric | 第一工业制药株式会社 | 2022-10-18 | — | — | CN | disclosed |
| WO-2021065325-A1 | PRIMER COMPOSITION | 第一工業製薬株式会社 | 2021-04-08 | — | — | WO | disclosed |
| EP-1856177-A1 | CARBOXYL GROUP-CONTAINING POLYURETHANE AND THERMOSETTING RESIN COMPOSITION USING THE SAME | Showa Denko K.K. (JP) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006093355-A1 | CARBOXYL GROUP-CONTAINING POLYURETHANE AND THERMOSETTING RESIN COMPOSITION USING THE SAME | SHOWA DENKO K.K. (JP) | 2006-09-08 | — | — | WO | disclosed |
| US-6852663-B2 | Double-metal cyanide catalysts for preparing polyether polyols | BAYER AKTIENGESELLSCHAFT (DE) | 2005-02-08 | — | — | US | disclosed |
| US-20030119663-A1 | Double-metal cyanide catalysts for preparing polyether polyols | BAYER AKTIENGESELLSCHAFT (DE) | 2003-06-26 | — | — | US | disclosed |