Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RARA | P10276 | 1/20 | 0.37 |
| ▸ | RARB | P10826 | 1/20 | 0.37 |
| ▸ | RARG | P13631 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9441687 | 0.74 | DRD3 (0.57) | TDP1 | |
| Hydrochloric Acid SCHEMBL9441693 | 0.73 | DRD3 (0.56) | TDP1 | |
| SCHEMBL5238494 | 0.72 | MTNR1A (0.45) | TDP1TAS1R3TAS1R1MTNR1AMAPT | |
| SCHEMBL5278012 | 0.72 | DRD3 (0.55) | TDP1 | |
| SCHEMBL5237994 | 0.72 | DRD3 (0.55) | TDP1 | |
| SCHEMBL25959765 | 0.72 | ROCK2 (0.53) | TDP1MTNR1AROCK2ALDH1A1MAPK1 | |
| SCHEMBL27927241 | 0.72 | TDP1 (0.55) | TDP1ROCK2ALDH1A1MAPK1RARA | |
| SCHEMBL5241204 | 0.71 | MTNR1A (0.44) | TAS1R3TAS1R1MTNR1AMAPTITGB3 | |
| SCHEMBL5238670 | 0.69 | MTNR1A (0.42) | TAS1R3TAS1R1MTNR1AMAPTITGB3 | |
| SCHEMBL5238113 | 0.68 | DRD3 (0.51) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819690-A2 | CHROMAN COMPOUNDS | Pfizer Limited (GB) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006056850-A2 | CHROMAN COMPOUNDS | PFIZER LIMITED (GB) | 2006-06-01 | — | — | WO | disclosed |