Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | DRD4 | P21917 | 4/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5241484 | 0.85 | BCHE (0.47) | MCL1TSHRALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5242772 | 0.82 | MCL1 (0.44) | MCL1P2RX4TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL5243272 | 0.80 | SMN1; SMN2 (0.52) | TSHRALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL5242793 | 0.79 | BCHE (0.54) | DRD2DRD4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL5278993 | 0.78 | BCHE (0.45) | MCL1TSHRALDH1A1LMNAMAPK1 | |
| SCHEMBL5279427 | 0.78 | CYP3A4 (0.41) | TSHRALDH1A1LMNAHTT | |
| SCHEMBL5288756 | 0.77 | MEN1 (0.54) | TSHRALDH1A1KDM4ELMNAHTT | |
| SCHEMBL5276997 | 0.76 | CA2 (0.45) | MCL1DRD2CA2CA9ALDH1A1 | |
| SCHEMBL5239213 | 0.74 | P2RX4 (0.44) | P2RX4KDM4E | |
| SCHEMBL5277209 | 0.74 | CA2 (0.41) | MCL1GFERTSHRCA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833797-A1 | AZACYCLIC COMPOUNDS AS INHBITORS OF SENSORY NEURONE SPECIFIC CHANNELS (SNS) | VERNALIS (R&D) LTD (GB) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006082354-A1 | AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC CHANNELS ( SNS ) | VERNALIS (R & D) LIMITED (GB) | 2006-08-10 | — | — | WO | disclosed |