Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31375513 | 0.84 | HDAC4 (0.43) | LMNATHRBKIF11ALDH1A1MAPT | |
| SCHEMBL15599291 | 0.82 | NPC1 (0.48) | ALDH1A1MAPTNPC1RAB9AKDM4E | |
| SCHEMBL17230034 | 0.82 | ALDH1A1 (0.44) | LMNATHRBKIF11ALDH1A1MAPT | |
| SCHEMBL1773246 | 0.82 | NPC1 (0.50) | LMNAKIF11ALDH1A1MAPTNPC1 | |
| SCHEMBL9951531 | 0.80 | KIF11 (0.57) | KIF11ALDH1A1MAPTNPC1HTT | |
| SCHEMBL26375533 | 0.80 | IKBKB (0.41) | ALDH1A1MAPTNPC1HTTRAB9A | |
| SCHEMBL4480260 | 0.80 | TRPV1 (0.50) | LMNATHRBKIF11ALDH1A1MAPT | |
| SCHEMBL27914438 | 0.79 | KIF11 (0.61) | LMNATHRBKIF11ALDH1A1MAPT | |
| SCHEMBL27932659 | 0.79 | CLK4 (0.47) | KIF11NPC1RAB9AKDM4EHPGD | |
| SCHEMBL10602510 | 0.79 | KIF11 (0.42) | LMNATHRBKIF11ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103626742-B | Bi-aryl meta-pyrimidine inhibitors of kinases | 塔格根公司 | 2017-04-26 | — | — | CN | disclosed |
| EP-1036066-B1 | SUBSTITUTED PYRIMIDINE AND PYRIDINE HERBICIDES | MID AMERICA COMMERCIALIZATION (US) | 2007-04-18 | — | — | EP | disclosed |
| US-20040033896-A1 | E.g., 5-ethyl-4-((3 -(trifluoromethoxy)phenyl)methyl)-2-(3-(trifluoromethyl)-1H pyrazol-1-yl)pyrimidine and 5-methyl-2-(4-(trifluoromethyl)phenyl)-4-((3-(trifluoromethyl) phenyl)methyl)pyrimidine | KOETHER GERARD (US) | 2004-02-19 | — | — | US | disclosed |
| US-6525001-B1 | 5-methyl-2-(4-(trifluoromethyl)phenyl)-4-((3 -(trifluoromethyl)phenyl)methyl)pyrimidine | MID-AMERICAN COMMERCIALIZATION CORPORATION | 2003-02-25 | — | — | US | disclosed |
| EP-1036066-A1 | SUBSTITUTED PYRIMIDINE AND PYRIDINE HERBICIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999028301-A1 | SUBSTITUTED PYRIMIDINE AND PYRIDINE HERBICIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1999-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040033896-A1 | E.g., 5-ethyl-4-((3 -(trifluoromethoxy)phenyl)methyl)-2-(3-(trifluoromethyl)-1H pyrazol-1-yl)pyrimidine and 5-methyl-2-(4-(trifluoromethyl)phenyl)-4-((3-(trifluoromethyl) phenyl)methyl)pyrimidine | PYM1, Q6ZSR9, MRM1 | LMNA 3056/4885THRB 3346/4885KIF11 2185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.