Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.51 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8577722 | 0.90 | CHRNB2 (0.44) | CHRNB2CHRNA7CHRNA4CYP2A6KDM1A | |
| SCHEMBL1741490 | 0.80 | SLC6A2 (0.53) | CHRNB2CHRNA7CHRNA4CYP2A6PRCP | |
| SCHEMBL1889514 | 0.79 | CHRNB2 (0.65) | CHRNB2CHRNA7CHRNA4CYP2A6PRCP | |
| SCHEMBL7510631 | 0.77 | CHRNB2 (0.53) | CHRNB2CHRNA7CHRNA4CYP2A6KDM1A | |
| SCHEMBL7037209 | 0.75 | CHRNB2 (0.44) | CHRNB2CHRNA7CHRNA4CYP2A6SLC6A2 | |
| SCHEMBL11631092 | 0.73 | CHRNB2 (0.45) | CHRNB2CHRNA7CHRNA4CYP2A6CA1 | |
| SCHEMBL7038235 | 0.72 | CHRNB2 (0.47) | CHRNB2CHRNA7CHRNA4CYP2A6SLC6A2 | |
| SCHEMBL24154698 | 0.71 | CHRNB2 (0.54) | CHRNB2CHRNA7CHRNA4CYP2A6TDP1 | |
| SCHEMBL10153581 | 0.70 | CHRNB2 (0.45) | CHRNB2CHRNA4KDM1ATDP1PRCP | |
| SCHEMBL9630207 | 0.70 | CHRNB2 (0.42) | CHRNB2CHRNA7CHRNA4CYP2A6TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751138-A1 | INDOL-2-ONE DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS DISORDERS, GASTROINTESTINAL DISORDERS AND CARDIOVASCULAR DISORDERS | EGIS Gyógyszergyár Nyrt (HU) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005108390-A1 | INDOL-2-ONE DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS DISORDERS, GASTROINTESTINAL DISORDERS AND CARDIOVASCULAR DISORDERS | EGIS GYÓGYSZERGYÁR NYRT. (HU) | 2005-11-17 | — | — | WO | disclosed |
| US-3951987-A | PSYCHOSEDATIVE | HOFFMANN-LA ROCHE INC. (US) | 1976-04-20 | — | — | US | disclosed |