Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.32 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5323612 | 0.88 | LTA4H (0.39) | LTA4HCA4L3MBTL1TAAR1SLC6A2 | |
| SCHEMBL1452863 | 0.86 | LTA4H (0.39) | LTA4HCA4NPSR1L3MBTL1TAAR1 | |
| SCHEMBL29068796 | 0.78 | LTA4H (0.39) | LTA4HCA4NPSR1L3MBTL1TAAR1 | |
| SCHEMBL183720 | 0.77 | LTA4H (0.40) | LTA4HCA4NPSR1L3MBTL1TAAR1 | |
| SCHEMBL27303841 | 0.77 | LTA4H (0.36) | LTA4HCA4TAAR1SLC6A2CHRNB2 | |
| SCHEMBL11259994 | 0.76 | LTA4H (0.38) | LTA4HCA4NPSR1L3MBTL1CHRNB2 | |
| SCHEMBL4980283 | 0.74 | ELANE (0.39) | LTA4HTSHR | |
| SCHEMBL28141859 | 0.74 | CA4 (0.42) | LTA4HCA4TAAR1SLC6A2KCNA3 | |
| SCHEMBL1454708 | 0.74 | LTA4H (0.46) | LTA4HSLC6A2KCNA3 | |
| SCHEMBL15292059 | 0.74 | LTA4H (0.37) | LTA4HCA4NPSR1L3MBTL1CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756107-A2 | ARYL-SUBSTITUTED PIPERAZINE DERIVATIVES | NEUROGEN CORPORATION (US) | 2007-02-28 | — | — | EP | claimed |
| WO-2006009789-A2 | ARYL-SUBSTITUTED PIPERAZINE DERIVATIVES | NEUROGEN CORPORATION (US) | 2006-01-26 | — | — | WO | claimed |