Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | CAMK1D | Q8IU85 | 14/20 | 0.47 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RIPK4 | P57078 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.46 |
| ▸ | CAMK1 | Q14012 | 1/20 | 0.46 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.46 |
| ▸ | PNCK | Q6P2M8 | 1/20 | 0.46 |
| ▸ | CAMK1G | Q96NX5 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8090998 | 0.78 | POLB (0.55) | POLBSMN1; SMN2CAMK1DPTPN11PDE4B | |
| SCHEMBL19261369 | 0.72 | P2RX3 (0.45) | HSP90AA1 | |
| SCHEMBL4569214 | 0.72 | NNMT (0.40) | HSP90AA1 | |
| Formic Acid SCHEMBL30422549 | 0.72 | PDE4B (0.50) | POLBSMN1; SMN2CAMK1DPIP5K1CCYP2C9 | |
| SCHEMBL30331571 | 0.71 | POLB (0.78) | POLBSMN1; SMN2PTPN11ALDH1A1LMNA | |
| SCHEMBL4790004 | 0.71 | POLB (0.49) | POLBSMN1; SMN2PTPN11ALDH1A1CASP1 | |
| SCHEMBL13667424 | 0.70 | CAMK1D (0.49) | POLBSMN1; SMN2CAMK1DPIP5K1CCYP2C9 | |
| SCHEMBL21399102 | 0.69 | POLB (0.42) | POLBSMN1; SMN2ALDH1A1HSP90AA1LMNA | |
| SCHEMBL9299149 | 0.69 | PTPN11 (0.60) | POLBSMN1; SMN2PTPN11ALDH1A1 | |
| SCHEMBL30309414 | 0.69 | POLB (0.45) | POLBSMN1; SMN2CAMK1DPTPN11PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809290-A2 | PYRIMIDINE DERIVATIVES AS ION CHANNEL MODULATORS AND METHODS OF USE | Vertex Pharmaceuticals Incorporated (US) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006050476-A2 | PYRIMIDINE DERIVATIVES AS ION CHANNEL MODULATORS AND METHODS OF USE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-05-11 | — | — | WO | disclosed |