Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.35 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28154323 | 0.82 | PDE4B (0.41) | PDE4BPDE4APDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL2503891 | 0.81 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL4555039 | 0.81 | GPR119 (0.48) | GPR119 | |
| SCHEMBL4555411 | 0.80 | GPR119 (0.52) | GPR119 | |
| SCHEMBL4554614 | 0.79 | GPR119 (0.53) | GPR119 | |
| SCHEMBL4553607 | 0.79 | GPR119 (0.44) | GPR119 | |
| SCHEMBL4433800 | 0.77 | GPR119 (0.41) | HSD11B1GPR119 | |
| SCHEMBL4555155 | 0.75 | GPR119 (0.50) | GPR119 | |
| SCHEMBL3824033 | 0.73 | PDE4B (0.45) | PDE4BPDE4APDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL310046 | 0.73 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784399-A2 | PYRIMIDINE DERIVATIVES | Novartis AG (CH) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006021457-A2 | PYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2006-03-02 | — | — | WO | disclosed |