Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.38 |
| ▸ | STS | P08842 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554614 | 0.87 | GPR119 (0.53) | GPR119NR1H2NR1H3 | |
| SCHEMBL4555039 | 0.84 | GPR119 (0.48) | GPR119NR1H2NR1H3JAK2JAK1 | |
| SCHEMBL4433800 | 0.83 | GPR119 (0.41) | GPR119NR1H2NR1H3JAK2JAK1 | |
| SCHEMBL4555411 | 0.82 | GPR119 (0.52) | GPR119NR1H2NR1H3 | |
| SCHEMBL5280717 | 0.79 | PDE4B (0.39) | GPR119 | |
| SCHEMBL4555155 | 0.77 | GPR119 (0.50) | GPR119 | |
| SCHEMBL4555034 | 0.73 | GPR119 (0.51) | GPR119 | |
| SCHEMBL4554607 | 0.71 | L3MBTL3 (0.38) | — | |
| SCHEMBL4555036 | 0.71 | GPR119 (0.37) | GPR119NR1H2NR1H3 | |
| SCHEMBL4555415 | 0.71 | GPR119 (0.39) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121661-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008085316-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 2008-07-17 | — | — | WO | disclosed |