Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 4/20 | 0.33 |
| ▸ | METAP1 | P53582 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10709995 | 0.78 | SMN1; SMN2 (0.44) | KDM4EGAAMEN1KMT2ALMNA | |
| SCHEMBL7368091 | 0.75 | MAPT (0.46) | MAPTKDM4EGAAHDAC3HDAC1 | |
| SCHEMBL193457 | 0.75 | IDO1 (0.49) | MAPTKDM4EGAAIDO1MEN1 | |
| SCHEMBL9437113 | 0.75 | KMT2A (0.38) | MAPTGAAMEN1KMT2ACYP3A4 | |
| SCHEMBL6195202 | 0.74 | KMT2A (0.34) | KDM4EIDO1MEN1KMT2ACYP3A4 | |
| SCHEMBL1515769 | 0.73 | IDO1 (0.46) | MAPTKDM4EGAAIDO1MEN1 | |
| SCHEMBL1155729 | 0.70 | MEN1 (0.42) | MAPTGAAIDO1MEN1KMT2A | |
| SCHEMBL4649295 | 0.70 | PKM (0.42) | MAPTKDM4EGAAHDAC3HDAC1 | |
| SCHEMBL29952704 | 0.69 | IDO1 (0.42) | MAPTGAAIDO1MEN1KMT2A | |
| SCHEMBL7759496 | 0.69 | KCNA5 (0.44) | MAPTKDM4EGAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006129120-A9 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2007-03-22 | — | — | WO | disclosed |
| WO-2006129120-A2 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2006-12-07 | — | — | WO | disclosed |