Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 4/20 | 0.36 |
| ▸ | METAP1 | P53582 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14862496 | 0.77 | OPRL1 (0.39) | IDO1CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL10433982 | 0.77 | METAP2 (0.52) | KDM4EIDO1DPP4DPP7METAP2 | |
| SCHEMBL9042917 | 0.75 | AOC1 (0.36) | GAAIDO1MEN1KMT2A | |
| SCHEMBL4649295 | 0.75 | PKM (0.42) | MAPTKDM4EGAAIDO1HDAC3 | |
| Hydrochloric Acid SCHEMBL10433975 | 0.75 | METAP2 (0.51) | KDM4EIDO1DPP4DPP7METAP2 | |
| SCHEMBL5280802 | 0.75 | MAPT (0.41) | MAPTKDM4EGAAIDO1DPP8 | |
| SCHEMBL5793032 | 0.74 | KEAP1 (0.47) | MAPTKDM4EGAAIDO1DPP8 | |
| Hydrochloric Acid SCHEMBL9042172 | 0.74 | AOC3 (0.38) | KDM4EGAAIDO1MEN1KMT2A | |
| SCHEMBL24742273 | 0.74 | IDO1 (0.58) | MAPTGAAIDO1DPP8DPP4 | |
| SCHEMBL2677265 | 0.74 | IDO1 (0.58) | MAPTGAAIDO1DPP8DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752981-B1 | SUBSTITUTED CYCLOPENTYLAMINE DERIVATIVES AND THEIR USE AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-06-09 | — | — | EP | disclosed |
| US-5817698-A | Substituted cycloalkylamine derivatives and their use as calcium channel antagonists | SMITHKLINE BEECHAM PLC (GB) | 1998-10-06 | — | — | US | disclosed |
| EP-0752981-A1 | SUBSTITUTED CYCLOALKYLAMINE DERIVATIVES AND THEIR USE AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-15 | — | — | EP | disclosed |
| WO-1995026327-A1 | SUBSTITUTED CYCLOALKYLAMINE DERIVATIVES AND THEIR USE AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-05 | — | — | WO | disclosed |
| EP-0105146-B1 | PROCESS FOR PREPARATION OF DIAMINES OR MIXTURES OF DIAMINES | BAYER AG (DE) | 1985-12-18 | — | — | EP | disclosed |
| EP-0104396-B1 | PROCESS FOR PREPARATION OF DIAMINES OR MIXTURES OF DIAMINES | BAYER AG (DE) | 1985-11-13 | — | — | EP | disclosed |
| EP-0105146-A1 | Process for preparation of diamines or mixtures of diamines | BAYER AG (DE) | 1984-04-11 | — | — | EP | disclosed |
| EP-0105146-A1 | Process for preparation of diamines or mixtures of diamines | BAYER AG (DE) | 1984-04-11 | — | — | EP | disclosed |
| EP-0104396-A1 | Process for preparation of diamines or mixtures of diamines | BAYER AG (DE) | 1984-04-04 | — | — | EP | disclosed |
| EP-0104396-A1 | Process for preparation of diamines or mixtures of diamines | BAYER AG (DE) | 1984-04-04 | — | — | EP | disclosed |