Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1748702 | 0.91 | SMN1; SMN2 (0.50) | SMN1; SMN2HTTNPSR1MAPTPDK2 | |
| SCHEMBL5277473 | 0.89 | HTR6 (0.58) | SMN1; SMN2HTTNPSR1HTR6MAPT | |
| SCHEMBL5279597 | 0.89 | SMN1; SMN2 (0.47) | SMN1; SMN2HTTNPSR1HTR6MAPT | |
| SCHEMBL5272631 | 0.82 | HTR6 (0.46) | HTTNPSR1HTR6MAPTP2RX7 | |
| SCHEMBL1748154 | 0.81 | SMN1; SMN2 (0.43) | SMN1; SMN2HTTNPSR1MAPTPDK2 | |
| SCHEMBL1748250 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2HTTNPSR1MAPTPDK2 | |
| SCHEMBL5280148 | 0.78 | ACLY (0.43) | SMN1; SMN2HTTNPSR1HTR6MAPT | |
| SCHEMBL14992409 | 0.77 | SMN1; SMN2 (0.48) | SMN1; SMN2HTTNPSR1MAPTPDK2 | |
| SCHEMBL5274095 | 0.75 | HTR6 (0.57) | SMN1; SMN2HTTHTR6MAPTMEN1 | |
| SCHEMBL1748342 | 0.75 | SMN1; SMN2 (0.52) | SMN1; SMN2HTTNPSR1MAPTP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856075-A1 | SUBSTITUTED ARYLAMINE COMPOUNDS AND THEIR USE AS 5-HT6 MODULATORS | Epix Delaware, Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006081332-A1 | SUBSTITUTED ARYLAMINE COMPOUNDS AND THEIR USE AS 5-HT6 MODULATORS | EPIX DELAWARE, INC. (US) | 2006-08-03 | — | — | WO | disclosed |