Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 3/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 4/20 | 0.39 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1748702 | 0.87 | SMN1; SMN2 (0.50) | ENPP2MEN1LMNAHTTKMT2A | |
| SCHEMBL1748204 | 0.87 | HTR6 (0.50) | ACLYHTTHTR6MAPTGAA | |
| Hydrochloric Acid SCHEMBL1748368 | 0.86 | HTR6 (0.49) | ACLYHTTHTR6MAPTGAA | |
| SCHEMBL5283022 | 0.78 | MAPT (0.45) | ACLYENPP2MEN1LMNAHTT | |
| SCHEMBL5280864 | 0.78 | SMN1; SMN2 (0.47) | MEN1LMNAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL5272631 | 0.77 | HTR6 (0.46) | HTTHTR6MAPTPOLBALDH1A1 | |
| SCHEMBL1748251 | 0.77 | ACLY (0.50) | ACLYMAPTALOX15 | |
| SCHEMBL1748250 | 0.74 | SMN1; SMN2 (0.51) | MEN1LMNAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL5389938 | 0.74 | HTR6 (0.42) | MEN1LMNAKMT2ASMN1; SMN2HTR6 | |
| SCHEMBL475619 | 0.72 | ADRB1 (0.46) | HTTHTR6MAPTGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856075-A1 | SUBSTITUTED ARYLAMINE COMPOUNDS AND THEIR USE AS 5-HT6 MODULATORS | Epix Delaware, Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006081332-A1 | SUBSTITUTED ARYLAMINE COMPOUNDS AND THEIR USE AS 5-HT6 MODULATORS | EPIX DELAWARE, INC. (US) | 2006-08-03 | — | — | WO | disclosed |