Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ANPEP | P15144 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11588025 | 0.86 | KEAP1 (0.52) | KMT2AMEN1GAACYP1A2CYP3A4 | |
| SCHEMBL7424677 | 0.85 | ALDH1A1 (0.57) | KMT2AMEN1GAAALDH1A1 | |
| SCHEMBL7386258 | 0.85 | ALDH1A1 (0.57) | KMT2AMEN1GAAALDH1A1 | |
| SCHEMBL28841583 | 0.80 | SMN1; SMN2 (0.55) | KMT2AMEN1GAACYP1A2CYP3A4 | |
| SCHEMBL1421427 | 0.79 | ALDH1A1 (0.58) | KMT2AMEN1SMN1; SMN2LMNAMAPT | |
| SCHEMBL7561830 | 0.79 | RAB9A (0.47) | L3MBTL1GAASMN1; SMN2LMNAMAPT | |
| SCHEMBL1421426 | 0.79 | ALDH1A1 (0.58) | KMT2AMEN1SMN1; SMN2LMNAMAPT | |
| SCHEMBL679864 | 0.79 | RAB9A (0.47) | L3MBTL1GAASMN1; SMN2LMNAMAPT | |
| SCHEMBL11871062 | 0.78 | GAA (0.49) | KMT2AMEN1L3MBTL1GAACYP1A2 | |
| SCHEMBL29169656 | 0.78 | KMT2A (0.49) | KMT2AMEN1GAACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403645-B2 | Antidepressant effect of norepinephrine uptake 2 inhibitors and combined medications including them | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2002-06-11 | — | — | US | claimed |
| US-20070116643-A1 | Novel aryloxypropanamines | CONCERT PHARMACEUTICALS INC. (US) | 2007-05-24 | — | — | US | disclosed |
| WO-2007005644-A2 | NOVEL ARYLOXYPROPANAMINES | CONCERT PHARMACEUTICALS INC. (US) | 2007-01-11 | — | — | WO | disclosed |