Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 18/20 | 0.70 |
| ▸ | THRB | P10828 | 18/20 | 0.70 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5287547 | 0.88 | THRB (0.73) | THRATHRBPPARG | |
| SCHEMBL5291080 | 0.85 | THRA (0.54) | THRATHRBPPARG | |
| SCHEMBL5281119 | 0.84 | THRA (0.83) | THRATHRB | |
| SCHEMBL5275174 | 0.84 | THRA (0.59) | THRATHRB | |
| SCHEMBL4358728 | 0.83 | THRA (1.00) | THRATHRBPPARG | |
| SCHEMBL5281917 | 0.82 | THRA (0.78) | THRATHRB | |
| SCHEMBL5278045 | 0.81 | THRB (0.48) | THRATHRBPPARG | |
| SCHEMBL5283381 | 0.81 | THRA (0.52) | THRATHRBPPARG | |
| SCHEMBL5280888 | 0.81 | THRA (0.57) | THRATHRB | |
| SCHEMBL5285435 | 0.81 | THRA (0.50) | THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1862450-A2 | Novel compounds | KARO BIO AB (SE) | 2007-12-05 | — | — | EP | disclosed |
| EP-1537073-B1 | BENZAMIDE OR PHENYLACETAMIDE DERIVATIVES USEFUL AS THYROID RECEPTOR LIGANDS | KAROBIO AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| EP-1537073-A2 | BENZAMIDE OR PHENYLACETAMIDE DERIVATIVES USEFUL AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004007430-A2 | BENZAMIDE OR PHENYLACETAMIDE DERIVATIVES USEFUL AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2004-01-22 | — | — | WO | disclosed |