Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 17/20 | 0.52 |
| ▸ | THRB | P10828 | 17/20 | 0.52 |
| ▸ | PPARG | P37231 | 3/20 | 0.52 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGAV | P06756 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2786552 | 0.87 | HSP90AB1 (0.63) | THRATHRBPPARGHSP90AB1TRPV1 | |
| SCHEMBL5282025 | 0.85 | THRB (0.52) | THRATHRBHSP90AB1 | |
| SCHEMBL5277954 | 0.84 | THRB (0.60) | THRATHRBPPARGHSP90AB1 | |
| SCHEMBL5280260 | 0.83 | THRB (0.68) | THRATHRBPPARGITGB3ITGAV | |
| SCHEMBL28680697 | 0.82 | HSP90AB1 (0.56) | THRATHRBHSP90AB1 | |
| SCHEMBL5281234 | 0.81 | THRA (0.70) | THRATHRBPPARG | |
| SCHEMBL5278045 | 0.81 | THRB (0.48) | THRATHRBPPARGHSP90AB1ITGB3 | |
| SCHEMBL1525224 | 0.80 | HSP90AB1 (0.54) | HSP90AB1TRPV1 | |
| SCHEMBL5279153 | 0.80 | THRB (0.55) | THRATHRB | |
| SCHEMBL29961027 | 0.80 | HSP90AB1 (0.58) | THRATHRBPPARGHSP90AB1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1862450-A2 | Novel compounds | KARO BIO AB (SE) | 2007-12-05 | — | — | EP | disclosed |
| EP-1537073-B1 | BENZAMIDE OR PHENYLACETAMIDE DERIVATIVES USEFUL AS THYROID RECEPTOR LIGANDS | KAROBIO AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| EP-1537073-A2 | BENZAMIDE OR PHENYLACETAMIDE DERIVATIVES USEFUL AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004007430-A2 | BENZAMIDE OR PHENYLACETAMIDE DERIVATIVES USEFUL AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2004-01-22 | — | — | WO | disclosed |