SCHEMBL5281695

SCHEMBL5281695

Cc1ccccc1-c1c(Cl)cccc1Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLA2G7 Q13093 1/20 0.47
MGAM O43451 1/20 0.43
GAA P10253 1/20 0.43
SI P14410 1/20 0.43
MGAM2 Q2M2H8 1/20 0.43
ELANE P08246 1/20 0.42
HSD11B1 P28845 1/20 0.42
TSHR P16473 3/20 0.41
LMNA P02545 1/20 0.41
ACHE P22303 1/20 0.41
CYP2A6 P11509 1/20 0.41
PBRM1 Q86U86 2/20 0.40
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
CASP3 P42574 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
SENP8 Q96LD8 1/20 0.40
SENP7 Q9BQF6 1/20 0.40
SENP6 Q9GZR1 1/20 0.40
MYC P01106 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4621499 0.86 ALDH1A1 (0.46) PLA2G7MGAMGAASIMGAM2
SCHEMBL21620288 0.84 CYP1A2 (0.46) PLA2G7HSD11B1TSHRACHENPC1
SCHEMBL521542 0.84 PLA2G7 (0.50) PLA2G7MGAMGAASIMGAM2
SCHEMBL4225651 0.82 HSP90AA1 (0.47) ELANELMNAFABP4GRIA1CACNG8
SCHEMBL16933911 0.82 S1PR4 (0.44) PLA2G7ELANEPBRM1PDK2CYP1A1
SCHEMBL11866840 0.81 MAPK13 (0.39) PLA2G7MGAMGAASIMGAM2
SCHEMBL29899283 0.81 ALDH1A1 (0.52) PLA2G7MGAMGAASIMGAM2
SCHEMBL321560 0.80 PLA2G7 (0.61) PLA2G7MGAMGAASIMGAM2
SCHEMBL2469822 0.79 CYP2A6 (0.55) HSD11B1TSHRLMNACYP2A6NPC1
SCHEMBL1133067 0.79 MYC (0.56) GAATSHRACHECYP2A6NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011007819-A1 PHARMACEUTICAL PRODUCT CONTAINING LACTAM OR BENZENE SULFONAMIDE COMPOUND 塩野義製薬株式会社 (JP) 2011-01-20 WO disclosed
EP-1313560-B1 CATALYST FOR AROMATIC C-O, C-N, and C-C BOND FORMATION UNIV YALE (US) 2007-12-19 EP disclosed
EP-1313560-A4 CATALYST FOR AROMATIC C-O, C-N, and C-C BOND FORMATION UNIV YALE (US) 2005-02-09 EP disclosed
EP-1313560-A1 CATALYST FOR AROMATIC C-O, C-N, and C-C BOND FORMATION YALE UNIVERSITY (US) 2003-05-28 EP disclosed
US-6562989-B2 Bicyclopentyl iron ligand and transition metal catalyst YALE UNIVERSITY 2003-05-13 US disclosed
US-20030008768-A1 Catalyst for aromatic C-O, C-N, and C-C bond formation NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2003-01-09 US disclosed
WO-2002011883-A1 CATALYST FOR AROMATIC C-O, C-N, and C-C BOND FORMATION YALE UNIVERSITY (US) 2002-02-14 WO disclosed