SCHEMBL5281999

SCHEMBL5281999

COCCCOc1cccc(OCCBr)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 3/20 0.57
CYP1A2 P05177 2/20 0.57
CYP2C19 P33261 2/20 0.57
CYP2D6 P10635 2/20 0.57
KDM4E B2RXH2 3/20 0.46
MEN1 O00255 1/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2C9 P11712 1/20 0.45
RECQL P46063 1/20 0.45
KMT2A Q03164 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
ALDH1A1 P00352 2/20 0.44
PRSS1 P07477 2/20 0.42
TSHR P16473 2/20 0.42
ALOX15 P16050 1/20 0.42
HSD17B10 Q99714 1/20 0.42
GAA P10253 1/20 0.42
NPC1 O15118 1/20 0.41
MAPT P10636 1/20 0.41
RAB9A P51151 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7062770 0.89 MAPK1 (0.57) MAPK1CYP1A2CYP2C19CYP2D6KDM4E
SCHEMBL8155382 0.86 SMN1; SMN2 (0.50) MAPK1CYP1A2CYP2C19CYP2D6CYP3A4
SCHEMBL1770655 0.85 MAPK1 (0.61) MAPK1CYP1A2CYP2C19MEN1CYP3A4
SCHEMBL30674601 0.85 MAPK1 (0.61) MAPK1CYP1A2CYP2C19MEN1CYP3A4
SCHEMBL7875701 0.83 TSHR (0.54) MAPK1CYP1A2CYP2C19CYP2D6CYP2C9
SCHEMBL4568911 0.83 MAPK1 (0.63) MAPK1CYP1A2CYP2C19CYP2D6KDM4E
SCHEMBL3978680 0.82 KDM4E (0.52) MAPK1CYP1A2CYP2C19CYP2D6KDM4E
SCHEMBL4745845 0.82 CYP2D6 (0.50) MAPK1CYP1A2CYP2C19CYP2D6KDM4E
SCHEMBL15173348 0.81 MAPK1 (0.57) MAPK1CYP1A2CYP2C19CYP2D6KDM4E
SCHEMBL2207185 0.81 MAPK1 (0.57) MAPK1CYP1A2CYP2C19CYP2D6KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011148392-A1 PROCESS FOR THE PREPARATION OF (2S,4S,5S,7S)-N-(2-CARBAMYL-2- METHYLPROPYL)-5-AMINO-4-HYDROXY-2,7-DIISOPROPYL-8-[4-METHOXY-3-(3- METHOXYPROPOXY)PHENYL]-OCTANAMIDE HEMIFUMARATE AND ITS INTERMEDIATES THEREOF MSN LABORATORIES LIMITED (IN) 2011-12-01 WO claimed
WO-2011148392-A1 PROCESS FOR THE PREPARATION OF (2S,4S,5S,7S)-N-(2-CARBAMYL-2- METHYLPROPYL)-5-AMINO-4-HYDROXY-2,7-DIISOPROPYL-8-[4-METHOXY-3-(3- METHOXYPROPOXY)PHENYL]-OCTANAMIDE HEMIFUMARATE AND ITS INTERMEDIATES THEREOF MSN LABORATORIES LIMITED (IN) 2011-12-01 WO disclosed
EP-1836163-A2 PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN Novartis AG (CH) 2007-09-26 EP disclosed
WO-2006066896-A2 PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN NOVARTIS AG (CH) 2006-06-29 WO disclosed