Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 9/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 9/20 | 0.38 |
| ▸ | VCP | P55072 | 2/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | DNMT3A | Q9Y6K1 | 2/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5283390 | 0.81 | SOS1 (0.43) | NR1H2NR1H3NR1I2NR3C1SOS1 | |
| SCHEMBL1407173 | 0.79 | NR1H2 (0.49) | NR1H2NR1H3VCPNR1I2NR3C1 | |
| SCHEMBL1408084 | 0.73 | NR1H2 (0.49) | NR1H2NR1H3VCPNR1I2NR3C1 | |
| SCHEMBL1407490 | 0.68 | NR1H2 (0.47) | NR1H2NR1H3VCPNR1I2NR3C1 | |
| SCHEMBL5348609 | 0.68 | NR1H2 (0.45) | NR1H2NR1H3NR1I2NR3C1 | |
| SCHEMBL27730583 | 0.67 | NR1H2 (0.47) | NR1H2NR1H3NR1I2NR3C1 | |
| SCHEMBL1408305 | 0.66 | NR1H2 (0.50) | NR1H2NR1H3NR1I2NR3C1DNMT3A | |
| SCHEMBL5244461 | 0.66 | ITGB2 (0.40) | NR1H2NR1H3NR1I2NR3C1SOS1 | |
| SCHEMBL3867717 | 0.66 | NR1H2 (0.66) | NR1H2NR1H3NR1I2NR3C1 | |
| SCHEMBL27730657 | 0.66 | NR1H2 (0.66) | NR1H2NR1H3NR1I2NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773781-A2 | INDAZOLES USEFUL IN TREATING CARDIOVASCULAR DISEASES | Wyeth (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2006017384-A2 | INDAZOLES USEFUL IN TREATING CARDIOVASCULAR DISEASES | WYETH (US) | 2006-02-16 | — | — | WO | claimed |