Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788719 | 0.80 | MEN1 (0.50) | S1PR1TDP1ALDH1A1POLBHPGD | |
| SCHEMBL7066582 | 0.73 | LMNA (0.49) | TDP1ALDH1A1LMNAL3MBTL1MAPT | |
| SCHEMBL3203718 | 0.72 | TDP1 (0.41) | TDP1ALDH1A1LMNAL3MBTL1POLB | |
| SCHEMBL11693495 | 0.70 | TDP1 (0.67) | TDP1ALDH1A1L3MBTL1MAPTNPC1 | |
| SCHEMBL2313725 | 0.66 | TDP1 (0.46) | TDP1ALDH1A1LMNAL3MBTL1MAPT | |
| SCHEMBL31658972 | 0.66 | GSTP1 (0.46) | TDP1ALDH1A1L3MBTL1POLBMAPT | |
| SCHEMBL2333611 | 0.66 | TDP1 (0.41) | TDP1ALDH1A1LMNAL3MBTL1POLB | |
| SCHEMBL17209987 | 0.66 | PARP1 (0.35) | TDP1ALDH1A1LMNAPOLBMAPT | |
| SCHEMBL626589 | 0.65 | ALDH1A1 (0.53) | TDP1ALDH1A1LMNAL3MBTL1POLB | |
| SCHEMBL29524625 | 0.65 | ALDH1A1 (0.53) | TDP1ALDH1A1LMNAL3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758873-A1 | UBIQUITIN LIGASE INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2006002284-A1 | UBIQUITIN LIGASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2006-01-05 | — | — | WO | disclosed |